Plasma N-terminal pro-B-type natriuretic peptide for prediction of death or nonfatal myocardial infarction following percutaneous coronary intervention

B-type natriuretic peptide (BNP) and the N-terminus of pro-BNP (NT–pro-BNP) have prognostic value in patients with heart failure and patients with acute coronary syndromes. Little is known about the prognostic value of baseline NT–pro-BNP alone or in combination with C-reactive protein (CRP) for cli...

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Bibliographic Details
Published in:The American journal of cardiology 2004-12, Vol.94 (12), p.1481-1485
Main Authors: de Winter, Robbert J., Stroobants, An, Koch, Karel T., Bax, Mattijs, Schotborgh, Carl E., Mulder, Karla J., Sanders, Gerard T., van Straalen, Jan P., Fischer, Johan, Tijssen, Jan G.P., Piek, Jan J.
Format: Article
Language:English
Subjects:
Aged
Angioplasty, Balloon, Coronary
Biological and medical sciences
Biomarkers - blood
C-Reactive Protein - analysis
Cardiology. Vascular system
Coronary heart disease
Diseases of the cardiovascular system
Female
Heart
Heart attacks
Heart failure
Humans
Male
Medical sciences
Mortality
Myocardial Infarction - blood
Myocardial Infarction - mortality
Myocarditis. Cardiomyopathies
Natriuretic Peptide, Brain
Nerve Tissue Proteins - blood
Peptide Fragments - blood
Peptides
Plasma
Prognosis
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Regression Analysis
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Summary:B-type natriuretic peptide (BNP) and the N-terminus of pro-BNP (NT–pro-BNP) have prognostic value in patients with heart failure and patients with acute coronary syndromes. Little is known about the prognostic value of baseline NT–pro-BNP alone or in combination with C-reactive protein (CRP) for clinical outcome after percutaneous coronary intervention (PCI). Within a single center registry of contemporaneous PCI, we investigated the prognostic value of baseline plasma NT–pro-BNP and CRP concentrations for the prediction of death or nonfatal myocardial infarction (MI) during 12 to 14 months of follow-up. Among 1,172 consecutive patients, the occurrence of death or MI increased significantly with baseline NT–pro-BNP before PCI (first quartile 0 of 294, second quartile 6 of 291 [2.1%], third quartile 4 of 294 [1.4%], fourth quartile 22 of 293 [7.5%)]; p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2004.08.023