Painless jaundice with serial multi-organ dysfunction

Autoimmune pancreatitis frequently mimics adeno carcinoma of the pancreas by causing painless jaundice, and has been diagnosed in 27% of patients undergoing the Whipple procedure.1 IgG4-related systemic disease can affect various organs and anatomical sites, including the pancreas, biliary tract, sa...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet (British edition) 2009-04, Vol.373 (9673), p.1494-1494
Main Authors: Khosroshahi, Arezou, Dr, Stone, James R, MD, Pratt, Daniel S, MD, Deshpande, Vikram, MD, Stone, John H, MD
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Blood & organ donations
Disease
General aspects
Humans
Immunoglobulin G
Internal Medicine
Jaundice
Jaundice - etiology
Male
Medical sciences
Medical treatment
Multiple Organ Failure - etiology
Paraproteinemias - complications
Paraproteinemias - diagnosis
Paraproteinemias - therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autoimmune pancreatitis frequently mimics adeno carcinoma of the pancreas by causing painless jaundice, and has been diagnosed in 27% of patients undergoing the Whipple procedure.1 IgG4-related systemic disease can affect various organs and anatomical sites, including the pancreas, biliary tract, salivary glands, retroperito neum, aorta, kidney, lung, and prostate.2,3 Most patients have marked increase of serum IgG4 concentrations. Tumorous swelling, diffuse lymphoplasmacytic infiltration, and obliterative phlebitis are common and have been reported in the setting of inflammatory abdominal aortic aneurysm.4 The disease occurs predominantly in older men, is frequently associated with lymphadenopathy, and responds well to glucocorticoid therapy.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(09)60615-2