Circulating concentrations of monocyte chemoattractant protein-1 are associated with menopause status in Korean women

Monocyte chemoattractant protein-1 (MCP-1) plays a role in adipose tissue inflammation and insulin resistance. Human circulating MCP-1 concentrations reportedly increase or remain unchanged according to obesity or insulin resistance in various ethnic populations; whether or not circulating MCP-1 con...

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Bibliographic Details
Published in:Clinica chimica acta 2009-05, Vol.403 (1), p.92-96
Main Authors: Park, Kang-Seo, Ahn, Kyu-Jeung, Kim, Byung-Joon, Kim, Hyun-Jin, Yoo, Seung Min, Kim, Ju-Young, Lee, Ki-Ho, Baik, Haing-Woon, Lee, Seong-Kyu
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group
Chemokine CCL2 - blood
Circulating MCP-1
Female
Humans
Insulin Resistance
Korea
Menopause
Menopause - blood
Middle Aged
Obesity
Obesity - blood
Postmenopause - blood
Premenopause - blood
Women
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Summary:Monocyte chemoattractant protein-1 (MCP-1) plays a role in adipose tissue inflammation and insulin resistance. Human circulating MCP-1 concentrations reportedly increase or remain unchanged according to obesity or insulin resistance in various ethnic populations; whether or not circulating MCP-1 concentrations increase after menopause has remained unclear. We investigated the relationship between circulating MCP-1 concentrations and obesity or insulin resistance, and the relationship between circulating MCP-1 and menopause status in premenopausal ( n = 111) and postmenopausal ( n = 64) Korean women. Circulating MCP-1 concentrations were significantly higher in postmenopausal women than in obesity-matched premenopausal women; they did not differ between non-obese and obese subgroups of pre- and postmenopausal women. Circulating MCP-1 concentrations had a relationship with menopause status ( ρ = 0.500, p = 0.000), irrespective of obesity, but no relationship with obesity or insulin resistance. Circulating MCP-1 concentrations correlated with serum triglycerides ( r = 0.4, p = 0.001) and also correlated with serum triglyceride concentrations, after adjusting for age and obesity, in postmenopausal women. Circulating MCP-1 concentrations are associated with menopause status itself, irrespective of obesity; they do not correlate with obesity or insulin resistance in Korean women, most of whom are not severely obese.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2009.01.025