The use of vinca alkaloids in adult patients with refractory chronic idiopathic thrombocytopenia

Summary The aim of the study was to evaluate the application of vincristin or vinblastin in patients with chronic idiopathic thrombocytopenic purpura (ITP), resistant to corticosteroids or with partial contraindication to their application. Twenty‐two patients were treated with vincristin or vinblas...

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Published in:Clinical and laboratory haematology 2004-12, Vol.26 (6), p.407-411
Main Authors: SIKORSKA, A., SŁOMKOWSKI, M., MAŚLANKA, K., KONOPKA, L., GÓRSKI, T.
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Adult
Aged
Female
Humans
Idiopathic thrombocytopenic purpura
Male
Middle Aged
Purpura, Thrombocytopenic, Idiopathic - drug therapy
Vinblastine - therapeutic use
vinca alkaloids
Vincristine - therapeutic use
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Summary:Summary The aim of the study was to evaluate the application of vincristin or vinblastin in patients with chronic idiopathic thrombocytopenic purpura (ITP), resistant to corticosteroids or with partial contraindication to their application. Twenty‐two patients were treated with vincristin or vinblastin in doses of 2 and 10 mg, respectively. Eight of these patients were additionally administered prednisone in an oral dose of 0.5 mg/kg body mass (bm). Two‐hour intravenous infusions of drugs were made once a week, at least three times. In every patient, the platelet count was evaluated before and after the three infusions. A rise of the platelet count of at least 100 × 109/l was assumed to signify improvement. Statistically significant improvement (P 
ISSN:0141-9854
1365-2257
DOI:10.1111/j.1365-2257.2004.00643.x