Hematopoietic stem cell transplantation in Langerhans cell histiocytosis: Case report and review of the literature

:  The prognosis in children with LCH who do not respond to the conventional therapies is very poor. SCT may be a new approach. However, there are limited data about the results of the transplantations. Herein we report a patient with refractory multisystem LCH who underwent allogeneic bone marrow t...

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Bibliographic Details
Published in:Pediatric transplantation 2009-05, Vol.13 (3), p.371-374
Main Authors: Kesik, Vural, Citak, Caglar, Kismet, Erol, Koseoglu, Vedat, Akyuz, Canan
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Bone Marrow Transplantation
Bone marrow, stem cells transplantation. Graft versus host reaction
Child, Preschool
children
Hematologic and hematopoietic diseases
Hematopoietic Stem Cell Transplantation
Histiocytosis, Langerhans-Cell - therapy
Humans
Langerhans cell histiocytosis
Male
Medical sciences
Other diseases. Hematologic involvement in other diseases
Prognosis
Remission Induction
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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Summary::  The prognosis in children with LCH who do not respond to the conventional therapies is very poor. SCT may be a new approach. However, there are limited data about the results of the transplantations. Herein we report a patient with refractory multisystem LCH who underwent allogeneic bone marrow transplantation and is disease and treatment free 54 months after transplantation. Further studies are required to establish the role of SCT in refractory LCH.
ISSN:1397-3142
1399-3046
DOI:10.1111/j.1399-3046.2008.00989.x