Serum TNF-alpha, IL-6, lupus anticoagulant and anticardiolipin antibody in women with and without a past history of recurrent miscarriage

• Published in: Archives of gynecology and obstetrics 2004-12, Vol.270 (4), p.227-229
• Main Authors: Arslan, Emine, Colakoğlu, Mehmet, Celik, Cetin, Gezginç, Kazim, Acar, Ali, Capar, Metin, Aköz, Mehmet, Akyürek, Cemalettin
• Format: Article
• Language: English
• Subjects: Abortion; Abortion, Habitual - blood; Adult; Antibodies, Anticardiolipin - blood; Anticoagulants; Case-Control Studies; Female; Humans; Interleukin-6 - blood; Lupus; Lupus Coagulation Inhibitor - blood; Medical Records; Pregnancy; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-003-0547-0

The aim of the this study was to investigate Lupus Anticoagulan (LA), Anticardiolipin Antibody (ACA), Tumor Necrosis Factor-alpha (TNF-alpha) and Interleukin-6 (IL-6) serum levels in 40 pregnant and 20 nonpregnant. The women were divided into three groups. The first group consisted of 20 pregnant women of less than 20 gestational weeks and a past history of habitual abortion . The second group consisted of 20 non pregnant patients with a past history of habitual abortion. The third group consisted of 20 healthy non pregnant women. LA was found in only one patient in the Group 2. ACA Ig G positivity were found 1 patient in the Group 1, 3 patients Group 2 and 1 patient in Group 3. Mean ACA IgG was highest in the Group 2. High serum TNF-alpha levels were found in the 12 (60%), 6(30%) and 2 (10%) women in the Groups 1, 2, and 3, respectively. Significant difference were found for TNF-alpha among the groups (P0.05). We propose that cytokines especially TNF-alpha was found to be related to the pregnancy loss.