Role of gastrointestinal permeability in exertional heatstroke

Reduced splanchnic blood flow and hyperthermia during exercise-heat stress can produce gastrointestinal barrier dysfunction and increased gastrointestinal permeability. This may allow endotoxin to enter the internal environment, causing local and systemic immune responses. These responses may be inv...

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Bibliographic Details
Published in:Exercise and sport sciences reviews 2004-10, Vol.32 (4), p.185-190
Main Author: Lambert, G Patrick
Format: Article
Language:English
Subjects:
Animals
Body Temperature Regulation - immunology
Capillary Permeability
Cytokines - blood
Endotoxemia - etiology
Endotoxemia - physiopathology
Fever - blood
Fever - physiopathology
Gastrointestinal Tract - blood supply
Gastrointestinal Tract - pathology
Heat Stroke - blood
Heat Stroke - immunology
Humans
Physical Exertion
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Summary:Reduced splanchnic blood flow and hyperthermia during exercise-heat stress can produce gastrointestinal barrier dysfunction and increased gastrointestinal permeability. This may allow endotoxin to enter the internal environment, causing local and systemic immune responses. These responses may be involved in the cause and outcome of exertional heatstroke. Countermeasures may reduce gastrointestinal permeability and possibly exertional heatstroke occurrence and outcome.
ISSN:0091-6331
DOI:10.1097/00003677-200410000-00011