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Role of gastrointestinal permeability in exertional heatstroke
Reduced splanchnic blood flow and hyperthermia during exercise-heat stress can produce gastrointestinal barrier dysfunction and increased gastrointestinal permeability. This may allow endotoxin to enter the internal environment, causing local and systemic immune responses. These responses may be inv...
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Published in: | Exercise and sport sciences reviews 2004-10, Vol.32 (4), p.185-190 |
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container_title | Exercise and sport sciences reviews |
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creator | Lambert, G Patrick |
description | Reduced splanchnic blood flow and hyperthermia during exercise-heat stress can produce gastrointestinal barrier dysfunction and increased gastrointestinal permeability. This may allow endotoxin to enter the internal environment, causing local and systemic immune responses. These responses may be involved in the cause and outcome of exertional heatstroke. Countermeasures may reduce gastrointestinal permeability and possibly exertional heatstroke occurrence and outcome. |
doi_str_mv | 10.1097/00003677-200410000-00011 |
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subjects | Animals Body Temperature Regulation - immunology Capillary Permeability Cytokines - blood Endotoxemia - etiology Endotoxemia - physiopathology Fever - blood Fever - physiopathology Gastrointestinal Tract - blood supply Gastrointestinal Tract - pathology Heat Stroke - blood Heat Stroke - immunology Humans Physical Exertion |
title | Role of gastrointestinal permeability in exertional heatstroke |
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