Protective constituents against sepsis in mice from the root cortex of Paeonia suffruticosa

The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root cortex of Paeonia suffruticosa ANDREWS (Ranunculaceae) led to the isolation of eight known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2), acetovanillone (3), paeonoside (4), paeoni...

Full description

Saved in:
Bibliographic Details
Published in:Archives of pharmacal research 2004-11, Vol.27 (11), p.1123-1126
Main Authors: Li, Gao, Seo, Chang-Seob, Lee, Kyeung-Seon, Kim, Hyo-Jin, Chang, Hyun-Wook, Jung, Jun-Sub, Song, Dong-Keun, Son, Jong-Keun
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Analysis of Variance
Animals
Male
Mice
Mice, Inbred ICR
Paeonia - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Roots - chemistry
Sepsis - blood
Sepsis - mortality
Sepsis - prevention & control
Survival Rate
Time Factors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root cortex of Paeonia suffruticosa ANDREWS (Ranunculaceae) led to the isolation of eight known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2), acetovanillone (3), paeonoside (4), paeoniflorin (5), oxypaeoniflorin (6), apiopaeonoside (7), and methyl 3-hydroxy-4-methoxybenzoate (8). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 17% for the control experiment) and reduced alanine aminotransferase level to be a half of the control value on the sepsis model induced by lipopolysaccharide/D-galactosamine.
ISSN:0253-6269
DOI:10.1007/BF02975116