Partial Protection Induced by a BHV-1 Recombinant Vaccine against Challenge with BHV-5

: Bovine herpesvirus type 5 (BHV‐5) is the causative agent of bovine herpetic encephalitis, a major concern for cattle farming in Brazil and Argentina. We recently developed a differential, gE‐negative vaccine (265 gE‐), based on a Brazilian BHV‐1 strain. The present study was carried out to examine...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2004-10, Vol.1026 (1), p.247-250
Main Authors: SPILKI, FERNANDO R., SILVA, ALESSANDRA D., HÜBNER, SILVIA, ESTEVES, PAULO A., FRANCO, ANA CLÁUDIA, DRIEMEIER, DAVID, ROEHEA, PAULO M.
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
BHV-1
BHV-5
Cattle
Cattle Diseases - immunology
Cattle Diseases - prevention & control
challenge
Encephalitis, Viral - immunology
Encephalitis, Viral - prevention & control
Encephalitis, Viral - veterinary
Herpesviridae Infections - immunology
Herpesviridae Infections - prevention & control
Herpesviridae Infections - veterinary
Herpesvirus
Herpesvirus 1, Bovine - immunology
Herpesvirus 5, Bovine - immunology
Herpesvirus 5, Bovine - pathogenicity
Meningoencephalitis - immunology
Meningoencephalitis - prevention & control
Meningoencephalitis - veterinary
protection
Vaccination - veterinary
vaccine
Viral Vaccines
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Summary:: Bovine herpesvirus type 5 (BHV‐5) is the causative agent of bovine herpetic encephalitis, a major concern for cattle farming in Brazil and Argentina. We recently developed a differential, gE‐negative vaccine (265 gE‐), based on a Brazilian BHV‐1 strain. The present study was carried out to examine whether such a vaccine would confer protection to BHV‐5 infections. It was concluded that the recombinant BHV‐1 vaccine tested here is not capable of conferring full protection to BHV‐5 challenge.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1307.038