Equine laminitis: A journey to the dark side of venous

Equine laminitis is a crippling condition that continues to defy repeated efforts to delineate the precise mechanisms involved and develop effective therapeutic strategies for use in the clinic. In this article, the possible role of dysfunction of the laminar vasculature is discussed, with particula...

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Bibliographic Details
Published in:Veterinary immunology and immunopathology 2009-06, Vol.129 (3), p.164-166
Main Authors: Robertson, Tom P., Bailey, Simon R., Peroni, John F.
Format: Article
Language:English
Subjects:
Animals
blood circulation
Foot Diseases - metabolism
Foot Diseases - pathology
Foot Diseases - veterinary
Hoof and Claw - blood supply
horse diseases
Horse Diseases - metabolism
Horse Diseases - pathology
Horses
Inflammation - metabolism
Inflammation - pathology
Inflammation - veterinary
laminae (animals)
Laminar arteries
Laminar microvasculature
Laminar veins
Laminitis
literature reviews
Metabolic syndrome
Oxygen Consumption
pathogenesis
Thrombosis
vascular diseases
Vascular dysfunction
Vasoconstriction
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Summary:Equine laminitis is a crippling condition that continues to defy repeated efforts to delineate the precise mechanisms involved and develop effective therapeutic strategies for use in the clinic. In this article, the possible role of dysfunction of the laminar vasculature is discussed, with particular emphasis on the venous side of the laminar microvasculature and the possible role(s) that metabolic syndrome and thrombosis may play in the dysfunction observed in the laminar microvasculature during the development of laminitis.
ISSN:0165-2427
1873-2534
DOI:10.1016/j.vetimm.2008.11.015