HLA-DP polymorphism in Venezuelan Amerindians

Three different Venezuelan Amerindian tribes were studied for human leukocyte antigen (HLA)-DPA1 and DPB1 allelic variability using polymerase chain reaction–sequence-specific oligonucleotide probes (PCR-SSOP) and sequence-based typing in a selected group of samples. These tribes are geographically...

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Bibliographic Details
Published in:Human immunology 2004-12, Vol.65 (12), p.1483-1488
Main Authors: Gendzekhadze, Ketevan, Herrera, Fidias, Montagnani, Silvia, Balbas, Omar, Witter, Klaus, Albert, Ekkehard, Layrisse, Zulay
Format: Article
Language:English
Subjects:
Alleles
Gene Frequency
Genetic Variation
Haplotypes
HLA-DP
HLA-DP alpha-Chains
HLA-DP Antigens - genetics
HLA-DP beta-Chains
Humans
Indians, South American - classification
Indians, South American - genetics
Linguistics
PCR-SSOP
Phylogeny
polymorphism
Polymorphism, Genetic
SBT
Venezuela
Venezuelan Amerindians
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Summary:Three different Venezuelan Amerindian tribes were studied for human leukocyte antigen (HLA)-DPA1 and DPB1 allelic variability using polymerase chain reaction–sequence-specific oligonucleotide probes (PCR-SSOP) and sequence-based typing in a selected group of samples. These tribes are geographically (two from the Perija Mountain range and one from the Orinoco Delta) and linguistically distinct: the Bari (from Campo Rosario and Saymaidoyi villages) and the Warao have been classified within the Chibcha linguistic family, whereas the Yucpa (from the Aroy, Marewa, and Peraya villages) are Carib speaking. Venezuelan Indians, like other Native American tribes, show a markedly reduced number of different HLA-DP alleles (range, 2–7) and haplotypes (range, 4–11) in comparison with neighboring Venezuelan mestizo and other non-Indian populations. Some HLA-DPB1 (*0402 and *1401) alleles characteristic for all Amerindian tribes are present also in these populations. Despite general similarities, each tribe and, in some cases, some subtribes show their own pattern of allele and haplotype distribution apparently more as a result of linguistic than to geographic variation.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2004.07.238