Fgf signaling components are associated with muscles and tendons during limb development

Muscle‐tendon interactions are important for the establishment of a functional musculoskeletal system. Fgf4 and Fgf8 are expressed in muscle and tendon boundary regions during limb development, suggesting a potential role for Fgf signaling pathway in muscle and tendon interactions. We have examined...

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Published in:Developmental dynamics 2009-05, Vol.238 (5), p.1195-1206
Main Authors: Eloy‐Trinquet, Sophie, Wang, Hui, Edom‐Vovard, Fréderic, Duprez, Delphine
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Animals
chick
Chick Embryo
Embryonic Development - genetics
Extremities - embryology
Fgf
Fibroblast Growth Factor 4 - metabolism
Fibroblast Growth Factor 8 - metabolism
Gene Expression
Intracellular Signaling Peptides and Proteins
limb
Membrane Proteins - genetics
Mesoderm - cytology
Mesoderm - metabolism
Mice
mouse
muscle
Muscle, Skeletal - embryology
Muscle, Skeletal - metabolism
Nerve Tissue Proteins - metabolism
Pea3
Phosphoproteins - genetics
Receptors, Fibroblast Growth Factor - metabolism
Signal Transduction - genetics
Sprouty
tendon
Tendons - embryology
Tendons - metabolism
Transcription Factors - metabolism
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Summary:Muscle‐tendon interactions are important for the establishment of a functional musculoskeletal system. Fgf4 and Fgf8 are expressed in muscle and tendon boundary regions during limb development, suggesting a potential role for Fgf signaling pathway in muscle and tendon interactions. We have examined the expression of Fgf syn‐expression group components during muscle and tendon formation of vertebrate limb development. We observed that the transcriptional effector of Fgf signaling, Pea3, and the modulators of Fgf signal, Sprouty1 and 2, were expressed in muscles and tendons and that their expression was enhanced at the myotendinous junctions in chick and mouse limbs. Analysis of Pea3 and Sprouty gene expression in muscleless limbs of Pax3 mutant mice indicated a major expression in muscles but also revealed that the Pea3 and Sprouty expression in tendons depended on muscles. Finally, our data showed that Fgf4 positively regulated Pea3, Sprouty1, and 2 expression in chick limb mesenchyme. Developmental Dynamics 238:1195–1206, 2009. © 2009 Wiley‐Liss, Inc.
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.21946