The Importance of Dendritic Mitochondria in the Morphogenesis and Plasticity of Spines and Synapses

The proper intracellular distribution of mitochondria is assumed to be critical for normal physiology of neuronal cells, but direct evidence for this idea is lacking. Extension or movement of mitochondria into dendritic protrusions correlates with the development and morphological plasticity of spin...

Full description

Saved in:
Bibliographic Details
Published in:Cell 2004-12, Vol.119 (6), p.873-887
Main Authors: Li, Zheng, Okamoto, Ken-Ichi, Hayashi, Yasunori, Sheng, Morgan
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
Creatine - pharmacology
Dendritic Spines - metabolism
Electric Stimulation - methods
Embryo, Mammalian - cytology
GTP Phosphohydrolases - metabolism
Hippocampus - cytology
Hippocampus - metabolism
Microtubule-Associated Proteins - metabolism
Mitochondria
Morphogenesis - drug effects
Morphogenesis - physiology
Neuronal Plasticity - drug effects
Neuronal Plasticity - physiology
Neurons - cytology
Neurons - metabolism
Pyramidal Cells - cytology
Pyramidal Cells - metabolism
Rats
Synapses - metabolism
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The proper intracellular distribution of mitochondria is assumed to be critical for normal physiology of neuronal cells, but direct evidence for this idea is lacking. Extension or movement of mitochondria into dendritic protrusions correlates with the development and morphological plasticity of spines. Molecular manipulations of dynamin-like GTPases Drp1 and OPA1 that reduce dendritic mitochondria content lead to loss of synapses and dendritic spines, whereas increasing dendritic mitochondrial content or mitochondrial activity enhances the number and plasticity of spines and synapses. Thus, the dendritic distribution of mitochondria is essential and limiting for the support of synapses. Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2004.11.003