Myelophil, an extract mix of Astragali Radix and Salviae Radix, ameliorates chronic fatigue: A randomised, double-blind, controlled pilot study

Summary Objectives To investigate the anti-fatigue effects of Myelophil, an extract of a mix of Astragali Radix and Salviae Radix, which has been used to treat patients with chronic fatigue. Subjects and design A randomised, double-blind, controlled clinical trial was performed with 36 adults who co...

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Bibliographic Details
Published in:Complementary therapies in medicine 2009-06, Vol.17 (3), p.141-146
Main Authors: Cho, J.H, Cho, C.K, Shin, J.W, Son, J.Y, Kang, W, Son, C.G
Format: Article
Language:English
Subjects:
Adult
Astragalus membranaceus
Automation
Chronic fatigue
Chronic fatigue syndrome
Cytokines
Cytokines - blood
Cytokines - immunology
Double-Blind Method
Drug dosages
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Fatigue Syndrome, Chronic - classification
Fatigue Syndrome, Chronic - drug therapy
Fatigue Syndrome, Chronic - immunology
Female
Health care
Herbal medicine
Humans
Internal Medicine
Male
Medical Education
Medicine
Middle Aged
Phytotherapy
Plant Extracts - immunology
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots
Plants, Medicinal
Salvia miltiorrhiza
Severity of Illness Index
Young Adult
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Summary:Summary Objectives To investigate the anti-fatigue effects of Myelophil, an extract of a mix of Astragali Radix and Salviae Radix, which has been used to treat patients with chronic fatigue. Subjects and design A randomised, double-blind, controlled clinical trial was performed with 36 adults who complained of chronic fatigue. The subjects were divided among a control group and low- and high-dose groups (3 or 6 g of oral Myelophil per day, respectively) and were monitored for 4 weeks. Fatigue severity was subjectively characterised, and the expression of 42 cytokines was evaluated using an antibody array. Results Myelophil administration (3 g per day) significantly decreased the fatigue severity score compared with the control ( p < 0.05). No changes were noted in cytokine expression. Conclusions Myelophil appears to have a pharmacological effect against fatigue, suggesting the clinical relevance of the traditional medicinal plants, Astragalus membranaceus and Salvia miltiorrhiza.
ISSN:0965-2299
1873-6963
DOI:10.1016/j.ctim.2008.11.003