Does Low Molecular Weight Heparin Impair Anastomotic Wound Healing?

Background Enoxaparin is an important molecule which had been using in prophylaxis and treatment of deep venous thrombosis. Also, it is showed that it prevents postsurgical peritoneal adhesions in rats. It is aimed to evaluate its effects on gastrointestinal wound healing. Methods Thirty Wistar albi...

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Bibliographic Details
Published in:Journal of gastrointestinal surgery 2009-04, Vol.13 (4), p.798-803
Main Authors: Ergul, Emre, Ozgun, Yigit Mehmet, Kiyak, Gulten, Barit Ozgun, Gonca, Korukluoglu, Birol, Kusdemir, Ahmet
Format: Article
Language:English
Subjects:
Anastomosis, Surgical
Animals
Blood vessels
Enoxaparin - pharmacology
Fibrinolytic Agents - administration & dosage
Fibrinolytic Agents - pharmacology
Gastroenterology
Hydroxyproline
Intestines - surgery
Medicine
Medicine & Public Health
Original Article
Rats
Rats, Wistar
Surgery
Surgical Wound Dehiscence - prevention & control
Tissue Adhesions - prevention & control
Wound healing
Wound Healing - drug effects
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Summary:Background Enoxaparin is an important molecule which had been using in prophylaxis and treatment of deep venous thrombosis. Also, it is showed that it prevents postsurgical peritoneal adhesions in rats. It is aimed to evaluate its effects on gastrointestinal wound healing. Methods Thirty Wistar albino rats were divided into three groups as control, subcutan, and intraperitoneal enoxaparin groups. Left colon anastomoses were performed. On postoperative seventh day, anastomotic healing was evaluated by measuring anastomotic bursting pressure, tissue hydroxyproline levels, and histopathological examination. Results The anastomotic bursting pressure was highest in subcutan enoxaparin group ( p  
ISSN:1091-255X
1873-4626
DOI:10.1007/s11605-008-0771-9