Infrequency of colonization with Oxalobacter formigenes in inflammatory bowel disease: Possible role in renal stone formation

Background and Aim:  Calcium oxalate renal stones (RS) and hyperoxaluria are common in patients with inflammatory bowel disease (IBD). The absence of intestinal oxalate degrading bacteria, Oxalobacter formigenes, may cause hyperoxaluria in IBD. The aim of the present study was to examine: (i) the co...

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Published in:Journal of gastroenterology and hepatology 2004-12, Vol.19 (12), p.1403-1409
Main Authors: KUMAR, RITU, GHOSHAL, UDAY C, SINGH, GUNJANA, MITTAL, RAMA D
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Crohn's disease
Female
Follow-Up Studies
Gastroenterology. Liver. Pancreas. Abdomen
Humans
hyperoxaluria
Inflammatory Bowel Diseases - complications
Inflammatory Bowel Diseases - microbiology
Inflammatory Bowel Diseases - urine
Kidney Calculi - etiology
Kidney Calculi - urine
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Other diseases. Semiology
Oxalobacter formigenes
Oxalobacter formigenes - growth & development
Oxalobacter formigenes - isolation & purification
renal stone
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
ulcerative colitis
Urinary lithiasis
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Summary:Background and Aim:  Calcium oxalate renal stones (RS) and hyperoxaluria are common in patients with inflammatory bowel disease (IBD). The absence of intestinal oxalate degrading bacteria, Oxalobacter formigenes, may cause hyperoxaluria in IBD. The aim of the present study was to examine: (i) the colonization of O. formigenes in patients with IBD and controls and to correlate its presence with urinary oxalate excretion; and (ii) urinary analytes contributing to RS in IBD. Methods:  Stool samples were studied for O. formigenes using polymerase chain reaction and Southern blotting in patients with IBD (n = 48: ulcerative colitis, 37; Crohn's disease, 11), RS (n = 87) and healthy subjects that were used as controls (n = 48). Levels of urinary oxalate, citrate, calcium, magnesium, creatinine and uric acid were estimated spectrophotometrically in each patient and in 13 controls for 24 h. Results:  Five of the 48 (10.4%) patients with IBD had RS. Five of the 48 (10.4%) patients with IBD, 25 of the 87 (29%) with RS and 27 of the 48 (56%) controls were colonized with O. formigenes (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2004.03510.x