Cysteine elevation in levodopa-treated patients with Parkinson's disease

Homocysteine, cysteine, and cysteinyl‐glycine are all metabolically interrelated. Levodopa/decarboxylase inhibitor (LD/DCI) administration increases total homocysteine (tHcy) plasma levels. Objectives were to investigate associations between LD/DCI intake, concentrations of tHcy, cysteine, and cyste...

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Bibliographic Details
Published in:Movement disorders 2009-04, Vol.24 (6), p.929-932
Main Authors: Müller, Thomas, Kuhn, Wilfried
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
Antiparkinson Agents - therapeutic use
Biological and medical sciences
Cohort Studies
cysteine
Cysteine - blood
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Glycine - blood
homocysteine
Humans
levodopa
Levodopa - therapeutic use
Linear Models
Male
Medical sciences
Middle Aged
Neurology
Parkinson Disease - blood
Parkinson Disease - drug therapy
Parkinson's disease
Severity of Illness Index
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Summary:Homocysteine, cysteine, and cysteinyl‐glycine are all metabolically interrelated. Levodopa/decarboxylase inhibitor (LD/DCI) administration increases total homocysteine (tHcy) plasma levels. Objectives were to investigate associations between LD/DCI intake, concentrations of tHcy, cysteine, and cysteinyl‐glycine in PD patients and healthy controls. Cysteine levels were significant lower in controls and PD patients with tHcy below the treshold of 15 [μmol/L] when compared with PD patients with tHcy above 15. Cysteinyl‐glycine did not significantly differ between the three cohorts. Significant associations appeared between tHcys and cysteine in PD patients. tHcy and cysteine concentrations correlated to LD/DCI intake and severity of PD. The cysteine increase may be due to the significant higher dosing of daily LD/DCI and the significant higher morning LD/DCI dose 1 hour before blood sampling in PD patients with tHcy above 15 when compared with the remaining PD patients and the controls. The correlation outcomes support the view that LD/DCI intake may also increase cysteine. © 2009 Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.22482