Label free colorimetric biosensing using nanoparticles

In this review article, we discuss a class of biosensors that exploit the change in the colorimetric properties of noble metal nanoparticles in response to biomolecular binding at their surface. Several sensor fabrication techniques as well as sensor configurations are discussed with an emphasis on...

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Bibliographic Details
Published in:Journal of fluorescence 2004-07, Vol.14 (4), p.377-389
Main Authors: Nath, Nidhi, Chilkoti, Ashutosh
Format: Article
Language:English
Subjects:
Algorithms
Biosensing Techniques - methods
Biosensing Techniques - trends
Colorimetry
Gold - chemistry
Gold - metabolism
Kinetics
Microchip Analytical Procedures - methods
Nanostructures - chemistry
Nanotechnology - methods
Nanotechnology - trends
Particle Size
Protein Binding
Proteins - metabolism
Silver - chemistry
Spectrophotometry
Surface Plasmon Resonance
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Summary:In this review article, we discuss a class of biosensors that exploit the change in the colorimetric properties of noble metal nanoparticles in response to biomolecular binding at their surface. Several sensor fabrication techniques as well as sensor configurations are discussed with an emphasis on their strengths and limitations. We conclude by presenting the future prospects and challenges for the successful transition of this technology from the laboratory to a commercial product.
ISSN:1053-0509
DOI:10.1023/B:JOFL.0000031819.45448.dc