Serum basic fibroblast growth factor as a marker of reflux nephropathy

The authors investigated whether serum basic fibroblast growth factor (b-FGF) can be used as a noninvasive marker of renal parenchymal damage (scarring) in cases of vesicoureteric reflux (VUR). Serum levels of b-FGF were measured in 120 children with known grade III to grade V VUR and 21 controls us...

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Bibliographic Details
Published in:Journal of pediatric surgery 2004-12, Vol.39 (12), p.1853-1855
Main Authors: Kobayashi, Hiroyuki, Miyakita, Hideshi, Yamataka, Atsuyuki, Koga, Hiroyuki, Lane, Geoffrey J., Miyano, Takeshi
Format: Article
Language:English
Subjects:
Adolescent
basic fibroblast growth factor
Biomarkers - blood
Child
Child, Preschool
Cicatrix - blood
Cicatrix - prevention & control
Female
Fibroblast Growth Factor 2 - blood
Humans
Infant
Male
reflux nephropathy
renal scarring
Vesico-Ureteral Reflux - blood
Vesico-Ureteral Reflux - complications
Vesicoureteral reflux
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Summary:The authors investigated whether serum basic fibroblast growth factor (b-FGF) can be used as a noninvasive marker of renal parenchymal damage (scarring) in cases of vesicoureteric reflux (VUR). Serum levels of b-FGF were measured in 120 children with known grade III to grade V VUR and 21 controls using a standard enzyme-linked immunosorbent assay technique. Sixty-five children had grade III VUR, 39 had grade IV, and 16 had grade V. Renal scarring was seen in 43 children on radionuclide scanning. There were no significant differences between serum b-FGF levels for different grades of VUR without scarring and controls. However, serum b-FGF levels were significantly higher in VUR patients with renal scarring than in patients with VUR without renal scarring ( P < .001). This report is the first to document serum b-FGF profiles in children with VUR and renal scarring. The authors recommend measuring it as a simple, noninvasive marker of renal scarring in cases of VUR.
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2004.08.014