Effect of Bupropion on Depression Symptoms in a Smoking Cessation Clinical Trial

Bupropion is an antidepressant shown to be efficacious for smoking cessation. This study examined the short- and long-term effects of bupropion (300 mg/day for 10 weeks) versus placebo on depression symptoms among 497 smokers attempting to quit in a randomized trial of bupropion plus behavioral coun...

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Bibliographic Details
Published in:Psychology of addictive behaviors 2004-12, Vol.18 (4), p.362-366
Main Authors: Lerman, Caryn, Niaura, Ray, Collins, Bradley N, Wileyto, Paul, Audrain-McGovern, Janet, Pinto, Angela, Hawk, Larry, Epstein, Leonard H
Format: Article
Language:English
Subjects:
Antidepressant Drugs
Antidepressive Agents, Second-Generation - therapeutic use
Biological and medical sciences
Bupropion
Bupropion - therapeutic use
Cessation
Combined Modality Therapy
Depression
Depressive Disorder - drug therapy
Desintoxication. Drug withdrawal
Directive Counseling
Drug Therapy
Female
Human
Humans
Major Depression
Male
Medical sciences
Middle Aged
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Smoking
Smoking Cessation
Smoking Cessation - methods
Smoking Cessation - psychology
Symptoms
Treatment
Treatments
USA
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Summary:Bupropion is an antidepressant shown to be efficacious for smoking cessation. This study examined the short- and long-term effects of bupropion (300 mg/day for 10 weeks) versus placebo on depression symptoms among 497 smokers attempting to quit in a randomized trial of bupropion plus behavioral counseling. Depression symptoms were assessed via the Center for Epidemiological Studies Depression Scale ( L. Radloff, 1977 ) at baseline, end of treatment, and at 6-month follow-up. Baseline nicotine dependence level was assessed with the Fagerström Test for Nicotine Dependence ( T. F. Heatherton, L. T. Kozlowski, R. C. Frecker, & K. O. Fagerström, 1991 ). A regression model of depression symptoms demonstrated a significant interaction between nicotine dependence and treatment for the treatment phase and during follow-up. Depression symptoms did not mediate the effects of bupropion on abstinence at either time point. Highly nicotine-dependent smokers who receive bupropion are more likely to experience a decrease in depressive symptoms during active treatment but are also more likely to experience a rebound in depressive symptoms when bupropion is discontinued.
ISSN:0893-164X
1939-1501
DOI:10.1037/0893-164X.18.4.362