Genetics of rheumatoid arthritis: Underlying evidence of ethnic differences

Abstract A new age has begun in the genetics of rheumatoid arthritis (RA), as genome-wide association studies scanning the human genome have been put into practical use. Among the RA-susceptibility genes identified by genetic studies, HLA-DRB1 gene appears to represent the most major determinant of...

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Bibliographic Details
Published in:Journal of autoimmunity 2009-05, Vol.32 (3), p.158-162
Main Authors: Kochi, Yuta, Suzuki, Akari, Yamada, Ryo, Yamamoto, Kazuhiko
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigens, CD - genetics
Antigens, CD - immunology
Arthritis, Rheumatoid - ethnology
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - immunology
Ethnic difference
Genetic predisposition
Genetic Predisposition to Disease
Genome-Wide Association Study
HLA-DR Antigens - genetics
HLA-DR Antigens - immunology
HLA-DRB1 Chains
Humans
Hydrolases - genetics
Hydrolases - immunology
Polymorphism, Genetic
Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 22 - immunology
Protein-Arginine Deiminases
Receptors, Immunologic - genetics
Receptors, Immunologic - immunology
Rheumatoid arthritis
Signaling Lymphocytic Activation Molecule Family
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Summary:Abstract A new age has begun in the genetics of rheumatoid arthritis (RA), as genome-wide association studies scanning the human genome have been put into practical use. Among the RA-susceptibility genes identified by genetic studies, HLA-DRB1 gene appears to represent the most major determinant of genetic predisposition to RA. However, inconsistent results of the contributions of non-HLA susceptibility genes have been described, with the exception of a few genes repeatedly associated with RA-susceptibility, such as PTPN22 gene in populations of European ancestry and PADI4 gene in populations of Asian ancestry, revealing the presence of genetic heterogeneity in RA. We review herein recent advances in the genetics of RA and discuss the underlying differences among populations of European and Asian ancestries, taking as examples our previous findings for RA-susceptibility genes in the Japanese population: PADI4; FCRL3; and CD244.
ISSN:0896-8411
1095-9157
DOI:10.1016/j.jaut.2009.02.020