Hepatitis C–related posttransplant plasma cell proliferative disorder with hepatitis C virus in neoplastic plasma cells: A new posttransplant disease entity?

Plasma cell proliferative disorder (PCPD) developed in two patients with actively replicating hepatitis C virus (HCV) in neoplastic plasma cells after orthotopic liver transplantation for HCV-related end-stage liver disease. PCPD was confined to the transplanted liver and was associated with monoclo...

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Bibliographic Details
Published in:Transplantation proceedings 2004-11, Vol.36 (9), p.2692-2696
Main Authors: Tun, H.W., Krishna, M., Menke, D.M.
Format: Article
Language:English
Subjects:
Antigens, CD - blood
B-Lymphocytes - immunology
B-Lymphocytes - pathology
B-Lymphocytes - virology
Biological and medical sciences
Blood Proteins - isolation & purification
Fatal Outcome
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Hepacivirus - physiology
Hepatitis C - surgery
Human viral diseases
Humans
Infectious diseases
Liver - pathology
Liver - virology
Liver Transplantation - pathology
Lymphoproliferative Disorders - pathology
Lymphoproliferative Disorders - virology
Male
Medical sciences
Middle Aged
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue, organ and graft immunology
Treatment Outcome
Viral diseases
Viral hepatitis
Virus Replication
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Description
Summary:Plasma cell proliferative disorder (PCPD) developed in two patients with actively replicating hepatitis C virus (HCV) in neoplastic plasma cells after orthotopic liver transplantation for HCV-related end-stage liver disease. PCPD was confined to the transplanted liver and was associated with monoclonal proteins in blood. Bone marrow biopsy did not show any evidence of PCPD. Epstein-Barr virus was not detected by in situ hybridization in either case. In situ hybridization for HCV RNA with sense and antisense probes in liver biopsy specimens showed signals in neoplastic plasma cells as well as in hepatocytes. We suggest that our patients had posttransplant PCPD resulting from HCV. It may represent a new posttransplant disease entity different from previously described posttransplant lymphoproliferative disorder. The findings raise intriguing questions about the role of HCV in PCPDs in patients with chronic HCV infection.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2004.09.058