Cross Dehydrogenative Arylation (CDA) of a Benzylic C----H Bond with Arenes by Iron Catalysis

Hooking up: FeCl₂ catalyzes the efficient cross dehydrogenative arylation of substrates having benzylic C---H bonds (see scheme). High regioselectivity was observed during the cross-coupling between compounds containing aromatic C(sp²)---H bonds and benzylic C(sp³)---H bonds. This process is propose...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (21), p.3817-3820
Main Authors: Li, Yi-Zhou, Li, Bi-Jie, Lu, Xing-Yu, Lin, Song, Shi, Zhang-Jie
Format: Article
Language:English
Subjects:
cross‐coupling
CH activation
iron
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Summary:Hooking up: FeCl₂ catalyzes the efficient cross dehydrogenative arylation of substrates having benzylic C---H bonds (see scheme). High regioselectivity was observed during the cross-coupling between compounds containing aromatic C(sp²)---H bonds and benzylic C(sp³)---H bonds. This process is proposed to proceed by single-electron-transfer oxidation and Friedel-Crafts alkylation.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200900341