Endothelial Markers in Schistosomiasis Patients With or Without Portal Hypertension

Purpose To evaluate the serum levels of von Willebrand factor (vWF), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), and endothelin-3 (ET-3) in patients with the isolated, inactive form of Schistosomiasis mansoni . Patients were classified into two groups: 10 patients without (SM gro...

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Bibliographic Details
Published in:Digestive diseases and sciences 2009-06, Vol.54 (6), p.1331-1336
Main Authors: de Toledo, Carlos Fischer, Carvente, Claudia Teresa, Shigueoka, David Carlos, Borges, Durval Rosa
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biochemistry
Biological and medical sciences
Biomarkers
Case-Control Studies
Diseases caused by trematodes
Endothelium, Vascular - metabolism
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology
Gastroenterology. Liver. Pancreas. Abdomen
Helminthic diseases
Hepatology
Humans
Hypertension, Portal - complications
Infectious diseases
Liver - blood supply
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Other diseases. Semiology
Parasitic diseases
Schistosoma
Schistosomiases
Schistosomiasis mansoni - blood
Schistosomiasis mansoni - complications
Transplant Surgery
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Young Adult
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Summary:Purpose To evaluate the serum levels of von Willebrand factor (vWF), vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), and endothelin-3 (ET-3) in patients with the isolated, inactive form of Schistosomiasis mansoni . Patients were classified into two groups: 10 patients without (SM group) and 18 with (PH group) portal hypertension. Results Serum albumin, VEGF, and vWF levels did not differ between the two groups ( P  > 0.05). The prothrombin time (INR), number of platelets, spleen size, splenic vein diameter, and endothelin levels differentiated the PH group, which showed decreased ET-1 (SM = 22.4 ± 2.4 pg/ml and PH = 16.4 ± 1.5 pg/ml; P  = 0.034) and increased ET-3 (SM = 2.1 ± 0.1 ng/ml and PH = 3.2 ± 0.1 ng/ml; P  = 0.000) levels. Conclusions In patients with schistosomiasis and portal hypertension (presinusoidal type), the levels of VEGF and ET-1 differ from those reported in patients with cirrhosis.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-008-0475-8