Adult-onset epilepsy and history of childhood febrile seizures: A retrospective study

BACKGROUND: Children with febrile seizures (FS) are at higher risk of developing epilepsy. There is robust literature on epilepsy with onset in childhood following FS but very little on the same issue in adults. AIMS: We intended to assess the association between adult-onset epilepsy and history of...

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Published in:Neurology India 2004-12, Vol.52 (4), p.463-465
Main Author: Mohebbi MohammadR, Navipour Reza, SeyedKazemi Mojdeh, Zamanian Hadi, Khamseh Fatemeh
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Care and treatment
Child
Diagnosis
Epilepsy
Epilepsy - epidemiology
Epilepsy - etiology
Febrile convulsions
Humans
Partial epilepsy, seizure, febrile seizure, convulsion, unprovoked, genetic
Retrospective Studies
Seizures, Febrile - complications
Seizures, Febrile - epidemiology
Seizures, Febrile - etiology
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Summary:BACKGROUND: Children with febrile seizures (FS) are at higher risk of developing epilepsy. There is robust literature on epilepsy with onset in childhood following FS but very little on the same issue in adults. AIMS: We intended to assess the association between adult-onset epilepsy and history of childhood FS. SETTINGS: The neurology clinic of a university hospital. DESIGN: A retrospective study. MATERIALS AND METHODS: Records of 101 consecutive adults (≥14 years old) who were referred to our hospital with adult-onset seizures were reviewed and the patients and their families were interviewed to assess the medical history. STATISTICAL ANALYSIS: Chi-square test and Mantel-Haenszel method. RESULTS: Of the 101 patients, 9 were excluded for reasons of bacterial meningitis, recent head trauma, brain tumor, tricyclic antidepressants′ overdose and missing reliable data of the childhood FS event. Thirty-one (33.7%) of the remaining 92 patients had history of FS in the childhood (71% men). Localization-related epilepsies were significantly associated with history of FS [Odds ratio: 3.29; (95% CI, 1.30-8.06)] ( χ2= 5.49, df = 1, P=0.012) when compared to other epilepsies and epilepsy syndromes. An initial unprovoked simple partial seizure was also significantly associated with a positive history of FS [Odds ratio: 8.05; (95% CI 2.88-22.45)] ( χ2= 15.86, df = 1, P
ISSN:0028-3886
1998-4022