Aviglycine and propargylglycine inhibit conidial germination and mycelial growth of Fusarium oxysporumf. sp. luffae

Two inhibitors, aviglycine and propargylglycine, were tested for their ability to suppress methionine synthesis thus inhibit conidial germination and mycelial growth of Czapek-Dox liquid medium grown Fusarium oxysporum f. sp. luffaemuM. The linear inhibition range for mycelial growth was about 7.6-7...

Full description

Saved in:
Bibliographic Details
Published in:Mycopathologia (1975) 2004-10, Vol.158 (3), p.369-375
Main Authors: Jin, Jung-Kang, Adams, Douglas O, Ko, Yeong, Yu, Chih-Wen, Lin, Chin-Ho
Format: Article
Language:English
Subjects:
Agricultural biotechnology
Alkynes - pharmacology
Antifungal Agents - pharmacology
Culture Media
Dose-Response Relationship, Drug
Enzymes
Fungi
Fungicides
Fusarium - drug effects
Fusarium - physiology
Fusarium oxysporum
Glycine - analogs & derivatives
Glycine - pharmacology
Homocysteine
Mycelium - drug effects
Pathogens
Plant diseases
Plant pathology
Polyamines
Spores, Fungal - drug effects
Spores, Fungal - physiology
Transfer RNA
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two inhibitors, aviglycine and propargylglycine, were tested for their ability to suppress methionine synthesis thus inhibit conidial germination and mycelial growth of Czapek-Dox liquid medium grown Fusarium oxysporum f. sp. luffaemuM. The linear inhibition range for mycelial growth was about 7.6-762.9 microM. Although aviglycine did not completely inhibit both conidial germination and mycelial growth, it showed significant inhibitory effect at 1.5 microM. The inhibition range for propargylglycine against conidial germination and mycelial growth were from 0.08 to 8841 microM and from 0.8 to 884.1 microM, respectively. Propargylglycine inhibited conidial germination and mycelial growth at a concentration of 8841 muM. The EC(50) values of aviglycine were 1 microM for conidial growth and 122 microM for mycelial growth, and the EC(50) values of propargylglycine were 47.7 microM for conidial growth and 55.6 muM for mycelial growth. Supplement of methionine released inhibition of aviglycine or propargylglycine to conidial germination. In addition, a mixture of aviglycine (1.5 microM) and propargylglycine (8841 microM) showed additive inhibitive effect than applied alone on 10 isolates. From these results, both aviglycine and propargylglycine exhibited inhibitory activity, and suggest that they can provide potential tools to design novel fungicide against fungal pathogens.
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-004-2225-6