Pregnancy-associated plasma protein A during hemodialysis with polyamide and diacetate cellulosic membranes

Pregnancy-associated plasma protein A (PAPP-A) is a new prognostic factor of acute coronary syndrome in the general population. It is elevated in hemodialysis (HD) patients and at baseline, it was shown to be related to inflammation and oxidative stress. The aim of the study was to examine the relat...

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Bibliographic Details
Published in:International journal of artificial organs 2004-11, Vol.27 (11), p.943-948
Main Authors: Kalousová, M, Lachmanová, J, Mokrejsová, M, Míková, B, Fialová, L, Malbohan, I M, Tesar, V, Zimá, T
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
Biomarkers - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - etiology
Cardiovascular Diseases - mortality
Cellulose - pharmacology
Cohort Studies
Female
Humans
Kidney Failure, Chronic - diagnosis
Kidney Failure, Chronic - mortality
Kidney Failure, Chronic - therapy
Male
Membranes, Artificial
Middle Aged
Nylons - pharmacology
Pregnancy-Associated Plasma Protein-A - analysis
Pregnancy-Associated Plasma Protein-A - metabolism
Probability
Prognosis
Prospective Studies
Renal Dialysis - adverse effects
Renal Dialysis - methods
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Statistics, Nonparametric
Survival Analysis
Treatment Outcome
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Summary:Pregnancy-associated plasma protein A (PAPP-A) is a new prognostic factor of acute coronary syndrome in the general population. It is elevated in hemodialysis (HD) patients and at baseline, it was shown to be related to inflammation and oxidative stress. The aim of the study was to examine the relationship of PAPP-A and oxidative stress and inflammatory markers to HD treatment. Studied parameters were determined in 10 chronic HD patients treated with low flux polyamide (1st session) and diacetate cellulosic membranes (2nd session) at the beginning, after 15 minutes and at the end of the dialysis session. TRACE method (Time Resolved Amplified Cryptate Emission) was used for PAPP-A assessment. Results were evaluated with ANOVA. PAPP-A levels did not depend on the type of HD membrane but changed significantly with the time of the HD session. They increased significantly from the beginning of HD to 15 min and then decreased to the end of the HD session - p
ISSN:0391-3988
1724-6040
DOI:10.1177/039139880402701106