Caspase inhibitor Z-VAD-FMK potentiates heat shock-induced apoptosis and HSP70 synthesis in macrophages

Caspase inhibitor Z-VAD-FMK potentiated heat shock-induced apoptosis in macrophages. Z-VAD-FMK did not activate HSP70 synthesis, but significantly increased the intensity of this process during heat shock. It cannot be excluded that caspases abolish HSP70 accumulation under these conditions. The HSP...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2004-09, Vol.138 (3), p.230-232
Main Authors: Malyshev, I Yu, Pshennikova, M G, Shimkovich, M V, Malysheva, E V
Format: Article
Language:English
Subjects:
Amino Acid Chloromethyl Ketones - pharmacology
Animals
Apoptosis
Caspase Inhibitors
Caspases - metabolism
Cysteine Proteinase Inhibitors - pharmacology
Heat-Shock Response
HSP70 Heat-Shock Proteins - antagonists & inhibitors
HSP70 Heat-Shock Proteins - metabolism
Macrophages - drug effects
Macrophages - enzymology
Male
Mice
Quercetin - pharmacology
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Summary:Caspase inhibitor Z-VAD-FMK potentiated heat shock-induced apoptosis in macrophages. Z-VAD-FMK did not activate HSP70 synthesis, but significantly increased the intensity of this process during heat shock. It cannot be excluded that caspases abolish HSP70 accumulation under these conditions. The HSP70 synthesis inhibitor quercetin potentiated DNA fragmentation in macrophages cocultured with Z-VAD-FMK after heat shock. HSP70 play an important role in the protection of macrophages from caspase-independent apoptosis.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0006-y