Glycoprotein 60 diversity in C. hominis and C. parvum causing human cryptosporidiosis in NSW, Australia

Management and control of cryptosporidiosis in human requires knowledge of Cryptosporidium species contributing to human disease. Markers that are able to provide information below the species level have become important tools for source tracking. Using the hypervariable surface antigen, glycoprotei...

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Bibliographic Details
Published in:Experimental parasitology 2009-06, Vol.122 (2), p.124-127
Main Authors: Waldron, L.S., Ferrari, B.C., Power, M.L.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cloning, Molecular
Cryptosporidiosis
Cryptosporidiosis - parasitology
Cryptosporidium
Cryptosporidium - classification
Cryptosporidium - genetics
Cryptosporidium parvum - classification
Cryptosporidium parvum - genetics
Diarrhoea
DNA, Protozoan - chemistry
DNA, Protozoan - isolation & purification
Feces - parasitology
Fundamental and applied biological sciences. Psychology
Genetic Variation
Genotype
Glycoproteins - genetics
GP60
Human disease
Humans
Life cycle. Host-agent relationship. Pathogenesis
New South Wales
Polymerase Chain Reaction
Protozoa
Sequence Analysis, DNA
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Summary:Management and control of cryptosporidiosis in human requires knowledge of Cryptosporidium species contributing to human disease. Markers that are able to provide information below the species level have become important tools for source tracking. Using the hypervariable surface antigen, glycoprotein 60 (GP60), C. hominis ( n = 37) and C. parvum ( n = 32) isolates from cryptosporidiosis cases in New South Wales, Australia, were characterised. Extensive variation was observed within this locus and the isolates could be divided into 8 families and 24 different subtypes. The subtypes identified have global distributions and indicate that anthroponotic and zoonotic transmission routes contribute to sporadic human cryptosporidiosis in NSW.
ISSN:0014-4894
1090-2449
DOI:10.1016/j.exppara.2009.02.006