Acquired immunodeficiency syndrome and the blood-brain barrier

The blood-brain barrier (BBB) plays a critical role in normal physiology of the central nervous system by regulating what reaches the brain from the periphery. The BBB also plays a major role in neurologic disease including neuropathologic sequelae associated with infection by human immunodeficiency...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neurovirology 2009-01, Vol.15 (2), p.111-122
Main Authors: Ivey, Nathan S, MacLean, Andrew G, Lackner, Andrew A
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - metabolism
Acquired Immunodeficiency Syndrome - physiopathology
Acquired Immunodeficiency Syndrome - virology
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Blood-Brain Barrier - pathology
Blood-Brain Barrier - physiology
Blood-Brain Barrier - virology
HIV - metabolism
HIV - pathogenicity
Human immunodeficiency virus
Human viral diseases
Humans
Immunology
Infectious Diseases
Inflammation - virology
Macaca
Macrophages - metabolism
Macrophages - virology
Medical sciences
Monocytes - metabolism
Monocytes - virology
Neurology
Neurosciences
Review
Simian immunodeficiency virus
Simian Immunodeficiency Virus - metabolism
Simian Immunodeficiency Virus - pathogenicity
Tight Junctions - metabolism
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral diseases of the nervous system
Virology
Virulence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The blood-brain barrier (BBB) plays a critical role in normal physiology of the central nervous system by regulating what reaches the brain from the periphery. The BBB also plays a major role in neurologic disease including neuropathologic sequelae associated with infection by human immunodeficiency virus (HIV) in humans and the closely related simian immunodeficiency virus (SIV) in macaques. In this review, we provide an overview of the function, structure, and components of the BBB, followed by a more detailed discussion of the subcellular structures and regulation of the tight junction. We then discuss the ways in which HIV/SIV affects the BBB, largely through infection of monocytes/macrophages, and how infected macrophages crossing the BBB ultimately results in breakdown of the barrier.
ISSN:1355-0284
1538-2443
DOI:10.1080/13550280902769764