Chemopreventive compounds—View from the other side

• Published in: Chemico-biological interactions 2009-06, Vol.180 (1), p.1-9
• Main Authors: Hodek, P., Křížková, J., Burdová, K., Šulc, M., Kizek, R., Hudeček, J., Stiborová, M.
• Format: Article
• Language: English
• Subjects: Anticarcinogenic Agents - therapeutic use; Cancer prevention; Cytochrome P-450 Enzyme System - metabolism; Cytochrome P450; Drug interactions; Flavonoids; Humans; Neoplasms - drug therapy; Neoplasms - physiopathology; Neoplasms - prevention & control; Phytochemicals; Risk Factors; Xenobiotics; Xenobiotics - metabolism; Xenobiotics - therapeutic use
• ISSN: 0009-2797; 1872-7786
• DOI: 10.1016/j.cbi.2009.01.003

Increasing attention is being paid to the possibility of applying chemopreventive agents for the protection of individuals from cancer risk. The beneficial potential of chemoprotective compounds is usually well documented by extensive experimental data. To assure the desired effect, these compounds are frequently concentrated to produce dietary supplements for human use. The additive and synergistic effects of other food constituents are, however, frequently ignored. Even natural chemopreventive compounds have to be considered as xenobiotics. Thus, as much attention has to be paid to their testing prior to their wide application as is usual in drug development for human treatment. Unfortunately, much of the research in this area is solely based on simplified in vitro systems that cannot take into account the complexity of biotransformation processes, e.g. chemopreventive compound–drug interaction, effect on metabolism of endogenic compounds. Hence, the predicted chemopreventive potential is not attained in respect of cancer prevention; moreover, the administration of high doses of chemopreventive compounds might be even detrimental for the human health.