Thyroid autoantibodies and their clinical relevance in young adults with type 1 diabetes during the first 12 yr after diabetes onset

In order to obtain prospective data on occurrence of thyroid autoantibodies [against thyroid peroxidase (antiTPO) and against thyroglobulin (antiTgl)] and their clinical relevance, we followed up on 109 young adults with Type 1 diabetes for 12 yr after diabetes onset. The patients were divided into...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2004-09, Vol.27 (8), p.728-732
Main Authors: Vondra, K, Vrbíková, J, Sterzl, I, Bílek, R, Vondrova, M, Zamrazil, V
Format: Article
Language:English
Subjects:
Adolescent
Adult
Autoantibodies - analysis
Autoantibodies - immunology
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - immunology
Disease Progression
Female
Follow-Up Studies
Humans
Hypothyroidism - immunology
Iodide Peroxidase - immunology
Male
Thyroid Function Tests
Thyroid Gland - diagnostic imaging
Thyroid Gland - immunology
Thyroiditis, Autoimmune - diagnostic imaging
Thyroiditis, Autoimmune - epidemiology
Thyroiditis, Autoimmune - immunology
Ultrasonography
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Summary:In order to obtain prospective data on occurrence of thyroid autoantibodies [against thyroid peroxidase (antiTPO) and against thyroglobulin (antiTgl)] and their clinical relevance, we followed up on 109 young adults with Type 1 diabetes for 12 yr after diabetes onset. The patients were divided into subgroup I [positivity of both thyroid autoantibodies (T-Ab); 25%, women predominantly], subgroup II (isolated antiTPO positivity only, 26%, men and women equally) and subgroup III (thyroid autoimmunity not present, 49%, men mainly). Cumulative incidence of T-Ab during the 12 yr of follow-up was 51% with predominance of women over men (65% vs 38%, p
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03347513