One-day or two-day procedure for sentinel node biopsy in melanoma?

Purpose We compared the outcome of a 1-day and a 2-day sentinel node (SN) biopsy procedure, evaluated in terms of lymphoscintigraphic, surgical and pathological findings. Methods We studied 476 patients with melanoma from two melanoma centres using static scintigraphy and blue dye. A proportional od...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2009-06, Vol.36 (6), p.928-937
Main Authors: Chakera, A. H., Lock-Andersen, J., Hesse, U., Nürnberg, B. M., Juhl, B. R., Stokholm, K. H., Drzewiecki, K. T., Hesse, B.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biopsy
Cardiology
Female
Humans
Imaging
Male
Medical imaging
Medical procedures
Medicine
Medicine & Public Health
Melanoma - diagnosis
Melanoma - diagnostic imaging
Melanoma - pathology
Melanoma - surgery
Middle Aged
Nuclear Medicine
Oncology
Original Article
Orthopedics
Radiology
Radionuclide Imaging
Sentinel Lymph Node Biopsy - methods
Skin cancer
Time Factors
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Summary:Purpose We compared the outcome of a 1-day and a 2-day sentinel node (SN) biopsy procedure, evaluated in terms of lymphoscintigraphic, surgical and pathological findings. Methods We studied 476 patients with melanoma from two melanoma centres using static scintigraphy and blue dye. A proportional odds model was used for statistical analysis. Results The number of SNs visualized at scintigraphy increased significantly with time from injection to scintigraphy and activity left in the patient at scintigraphy, and depended on the melanoma location. The number of SNs removed at surgery increased with the number of SNs visualized at scintigraphy and time from injection to surgery. The frequency of nodal metastasis increased with increasing thickness and Clark level of the melanoma, and was highest for two SNs visualized at scintigraphy. Conclusion This study showed that early vs. late imaging and surgery do make a difference on the outcome of the SN procedure and confirmed the importance of the scintigraphic visualization of all true SNs.
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-008-1036-2