Total synthesis of norneolignans from Krameria species

The total synthesis of nomeolignans isolated from Krameria species, 2-aryl-5-(E)-propenylbenzofurans (5, 11), is described. The key step involves the one-pot reaction for 2-arylbenzofurans (2, 7) from 4-hydroxyphenylacetone with 4'-acetoxy-2-chloro-2-(methylthio)acetophenone (1) and 2-chloro-2-...

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Bibliographic Details
Published in:Archives of pharmacal research 2004-12, Vol.27 (12), p.1189-1193
Main Authors: Seo, Pil-Ja, Choi, Hong-Dae, Son, Byeng-Wha
Format: Article
Language:English
Subjects:
Krameriaceae
Lignans - chemical synthesis
Lignans - isolation & purification
Plant Extracts - chemical synthesis
Plant Extracts - isolation & purification
Plant Roots
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Summary:The total synthesis of nomeolignans isolated from Krameria species, 2-aryl-5-(E)-propenylbenzofurans (5, 11), is described. The key step involves the one-pot reaction for 2-arylbenzofurans (2, 7) from 4-hydroxyphenylacetone with 4'-acetoxy-2-chloro-2-(methylthio)acetophenone (1) and 2-chloro-2-methylthio-(2',4',6'-trimethoxy)acetophenone (6) under Friedel-Crafts reactionconditions.
ISSN:0253-6269
DOI:10.1007/BF02975879