Survival analysis of resection of lung metastases from colorectal cancer

• Published in: Archivos de bronconeumología 2009-05, Vol.45 (5), p.235-239
• Main Authors: Mongil Poce, Roberto, Pagés Navarrete, Carlos, Ruiz Navarrete, José Antonio, Roca Fernández, Javier, Arrabal Sánchez, Ricardo, Benítez Doménech, Agustín, Fernández de Rota Avecilla, Antonio, Fernández Bermúdez, José Luis
• Format: Article
• Language: Spanish
• Subjects: Adenocarcinoma - mortality; Adenocarcinoma - secondary; Adenocarcinoma - surgery; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms - mortality; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms - mortality; Lung Neoplasms - secondary; Lung Neoplasms - surgery; Male; Middle Aged; Pneumonectomy - methods; Pneumonectomy - statistics & numerical data; Prognosis; Retrospective Studies; Risk Factors
• ISSN: 0300-2896
• DOI: 10.1016/j.arbres.2008.11.008

The publication of the International Registry of Lung Metastases (IRLM) in 1997 was a turning point in favor of surgical resection of lung metastases. Prognostic groups were defined according to resectability, number of metastases, and disease-free interval. The objective of this study was to determine survival in patients who underwent resection of lung metastases from colorectal carcinoma and to evaluate how applicable the prognostic factors established by the IRLM are in this specific patient group. Patients with lung metastases from colorectal carcinoma who underwent resection between January 1, 2000, and November 30, 2006, were retrospectively analyzed. Survival was calculated using the Kaplan-Meier method, with log-rank comparisons between groups. Survivals at 1, 3, 5, and 6 years was 92%, 75%, 54%, and 43%, respectively. The main finding was that 3-year survival was better in patients who underwent atypical resection of the metastasis (75%) than those who required lobectomy (55%). There were no significant differences in survival in terms of number of lung metastases resected or disease-free interval. Survival in patients requiring lobectomy for resection of lung metastases from colorectal carcinoma was worse than in those who underwent atypical resection. The number of metastases and disease-free interval may be questionable prognostic factors in the case of lung metastases from colorectal carcinoma.