Association of autoantibodies against small nuclear ribonucleoproteins (snRNPs) with symptomatic Toxocara canis infestation

SUMMARY Several studies have demonstrated the occurrence of autoantibodies in the course of infestations with helminth parasites and a number of target proteins have been identified. Sera from patients suffering from toxocarosis, a disease caused by the parasitic roundworm Toxocara canis, and from h...

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Bibliographic Details
Published in:Parasite immunology 2004-08, Vol.26 (8‐9), p.327-333
Main Authors: Obwaller, Andreas, Duchêne, Michael, Walochnik, Julia, Wiedermann, Gerhard, Auer, Herbert, Aspöck, Horst
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Antibodies, Antinuclear - immunology
Antibodies, Helminth - blood
Antibodies, Helminth - immunology
autoantibodies
Autoantibodies - immunology
autoimmunity
Cell Line, Tumor
Child
Child, Preschool
Female
Fluorescent Antibody Technique, Indirect
Humans
Immunoblotting
Male
Middle Aged
Ribonucleoproteins, Small Nuclear - immunology
small nuclear ribonucleoproteins
Statistics, Nonparametric
Toxocara
Toxocara canis
Toxocara canis - immunology
Toxocariasis - immunology
Toxocariasis - parasitology
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Summary:SUMMARY Several studies have demonstrated the occurrence of autoantibodies in the course of infestations with helminth parasites and a number of target proteins have been identified. Sera from patients suffering from toxocarosis, a disease caused by the parasitic roundworm Toxocara canis, and from healthy individuals were tested for autoantibodies by immunofluorescence and immunoblot assays using HEp‐2 cells as antigen. A considerable proportion of the sera from patients with toxocarosis‐associated symptoms were autoantibody‐positive, with a speckled staining pattern in the immunofluorescence test (62%) and with anti‐snRNP reactivity in the immunoblot assay (98%). In contrast, significantly fewer sera from asymptomatic individuals scored positive in these assays (18% in the immunofluorescence test, P 
ISSN:0141-9838
1365-3024
DOI:10.1111/j.0141-9838.2004.00716.x