Molecular and chromosomal mutations among children with B-lineage lymphoblastic leukemia in Brazil's Federal District

Acute lymphoblastic leukemia (ALL) accounts for approximately 80% of all acute leukemias during childhood. Chromosomal anomalies resulting from gene fusion, which are frequent in leukemias, create hybrid transcripts, the great majority of which encode transcription factors. We analyzed 88 pediatric...

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Bibliographic Details
Published in:Genetics and molecular research 2009-01, Vol.8 (1), p.345-353
Main Authors: Mesquita, D R, Córdoba, J C, Magalhães, I Q, Córdoba, M S, Oliveira, J R C, Gonçalves, A, Ferrari, I, Martins-de-Sá, C
Format: Article
Language:English
Subjects:
Brazil
Cell Lineage
Child
Chromosome Aberrations
Databases, Genetic
Female
Humans
Immunophenotyping
Male
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - metabolism
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Summary:Acute lymphoblastic leukemia (ALL) accounts for approximately 80% of all acute leukemias during childhood. Chromosomal anomalies resulting from gene fusion, which are frequent in leukemias, create hybrid transcripts, the great majority of which encode transcription factors. We analyzed 88 pediatric patients (median age 7.3 years) who had B-lineage acute lymphoblastic leukemia (B-ALL), using reverse transcriptase-polymerase chain reaction, to look for gene fusion transcripts of TEL/AML1, E2A/PBX1, BCR/ABL p190, and MLL/AF4. The frequencies of these transcripts were 21.21, 9.68, 3.03, and 0%, respectively. All positive cases had a common B-ALL immunophenotype. The low frequency of the TEL/AML1 transcript that is found in developing countries, such as Brazil, may be due to the low incidence of leukemia; this would support Greaves' hypothesis.
ISSN:1676-5680
1676-5680
DOI:10.4238/vol8-1gmr582