Oligodendrocyte positioning in cerebral cortex is independent of projection neuron layering

The factors affecting normal oligodendrocyte positioning in the cerebral cortex are unknown. Apart from the white matter, the highest numbers of oligodendrocytes in the rodent cortex are found in Layers V/VI, where the infragranular neurons normally reside. Few, if any, oligodendrocytes are normally...

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Bibliographic Details
Published in:Glia 2009-07, Vol.57 (9), p.1024-1030
Main Authors: Tan, Seong-Seng, Kalloniatis, Michael, Truong, Hue-Trung, Binder, Michele D., Cate, Holly S., Kilpatrick, Trevor J., Hammond, Vicki E.
Format: Article
Language:English
Subjects:
2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism
Adaptor Proteins, Signal Transducing - genetics
Animals
Cell Adhesion Molecules, Neuronal - genetics
Cerebral Cortex - anatomy & histology
Cerebral Cortex - cytology
Cerebral Cortex - metabolism
Dab1
Extracellular Matrix Proteins - genetics
Immunohistochemistry
Mice
Mice, Mutant Strains
Mice, Neurologic Mutants
neocortex
Nerve Fibers, Myelinated - physiology
Nerve Tissue Proteins - genetics
Neurons - cytology
Neurons - physiology
oligodendrocytes
Oligodendroglia - cytology
Oligodendroglia - metabolism
p35
Phosphotransferases - genetics
Reelin
Serine Endopeptidases - genetics
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Summary:The factors affecting normal oligodendrocyte positioning in the cerebral cortex are unknown. Apart from the white matter, the highest numbers of oligodendrocytes in the rodent cortex are found in Layers V/VI, where the infragranular neurons normally reside. Few, if any, oligodendrocytes are normally found in the superficial cortical layers. To test whether or not this asymmetric positioning of oligodendrocytes is linked to the lamina positions of Layer V/VI projection neurons, mutant mice that cause neuronal layer inversion were examined. In three lines of mutant mice (Reeler, disabled‐1, and p35) examined, representing two different genetic signaling pathways, the oligodendrocyte distribution was altered from an asymmetric to a symmetric distribution pattern. Unlike cortical neurons that are inverted in these mutant mice, the lack of oligodendrocyte inversion suggests a decoupling of the genetic mechanisms governing neuronal versus oligodendrocyte patterning. We conclude that oligodendrocyte positioning is not linked to the layer positions of V/VI projection neurons. © 2008 Wiley‐Liss, Inc.
ISSN:0894-1491
1098-1136
DOI:10.1002/glia.20826