Does Intensity-modulated Stereotactic Radiotherapy Achieve Superior Target Conformity than Conventional Stereotactic Radiotherapy in Different Intracranial Tumours?

Abstract Aims To compare the dosimetric outcome of various conventional stereotactic radiotherapy (SRT) techniques with intensity-modulated stereotactic radiotherapy (IMSRT) in brain tumours of varying shape, size, location and proximity to organs at risk (OARs). Materials and methods Fused computed...

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Bibliographic Details
Published in:Clinical oncology (Royal College of Radiologists (Great Britain)) 2009-06, Vol.21 (5), p.408-416
Main Authors: Sharma, S.D, Jalali, R, Phurailatpam, R.D, Gupta, T
Format: Article
Language:English
Subjects:
Brain Neoplasms - pathology
Brain Neoplasms - radiotherapy
Brain Stem
Brain tumour
Child
conformity index
Cranial Irradiation - methods
Hematology, Oncology and Palliative Medicine
Humans
IMSRT
Radiology
Radiosurgery
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Intensity-Modulated
SRT
Temporal Lobe
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Summary:Abstract Aims To compare the dosimetric outcome of various conventional stereotactic radiotherapy (SRT) techniques with intensity-modulated stereotactic radiotherapy (IMSRT) in brain tumours of varying shape, size, location and proximity to organs at risk (OARs). Materials and methods Fused computed tomography and magnetic resonance imaging datasets of four patients with different brain tumours previously treated with non-coplanar static conformal fields (SCF) were re-planned on the BrainScan treatment planning system using non-coplanar conformal arcs (CA), dynamic conformal arcs (DCA) and IMSRT with coplanar (IMSRT_CP) or non-coplanar (IMSRT_NCP) beam arrangement. Beam shaping and intensity modulation were carried out using a BrainLab micromultileaf collimator. The primary objective for each plan was to encompass ≥99% of the planning target volume (PTV) by >95% of the prescribed dose while minimising the dose to OARs. Results The mean PTV coverage in SCF, CA, DCA, IMSRT_NCP and IMSRT_CP was 99.2, 99.5, 99.4, 99.2 and 99.2%, respectively. The highest dose within the target was
ISSN:0936-6555
1433-2981
DOI:10.1016/j.clon.2009.02.002