Cyclooxygenase-2 expression in the hereditary mixed polyposis syndrome

Hereditary mixed polyposis syndrome (HMPS), characterized by hyperplastic, juvenile, admixed, serrated adenomas and eventually colorectal cancer, is managed by repeated polypectomy and surgery. We determined if HMPS polyps express cyclooxygenase-2 (COX-2). Nineteen recent HMPS polyps, from five fami...

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Bibliographic Details
Published in:Digestive diseases and sciences 2004-11, Vol.49 (11-12), p.1906-1911
Main Authors: BRAZOWSKI, Eli, MISONZHNICK-BEDNY, Faina, ROZEN, Paul
Format: Article
Language:English
Subjects:
Adenomatous Polyposis Coli - enzymology
Adenomatous Polyposis Coli - pathology
Biological and medical sciences
Cyclooxygenase 2
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunohistochemistry
Isoenzymes - biosynthesis
Medical sciences
Membrane Proteins
Prostaglandin-Endoperoxide Synthases - biosynthesis
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Hereditary mixed polyposis syndrome (HMPS), characterized by hyperplastic, juvenile, admixed, serrated adenomas and eventually colorectal cancer, is managed by repeated polypectomy and surgery. We determined if HMPS polyps express cyclooxygenase-2 (COX-2). Nineteen recent HMPS polyps, from five family members, were stained for COX-2. Polyps' epithelium and stroma and comparison tissues (normal colonic mucosa [9], sporadic juvenile polyps [18], colorectal cancers [3]) were quantified for COX-2 by: area of staining (0-3) x intensity (0-3). Epithelial, stromal, and total scores were evaluated in relationship to histology and dysplasia. HMPS polyps COX-2 mean epithelial (5.0+/-3.0), stromal (6.9+/-1.9), and total (11.8+/-4.6) scores were significantly higher (P < 0.01) than sporadic juvenile polyps (0.6+/-0.7, 3.1+/-2.2, and 3.6+/- 2.2 respectively), while colorectal cancer scored 9, 9, and 18. There was a positive association (P < 0.01) among histology, degree of dysplasia, and COX-2 expression. COX-2 expression in HMPS polyps and its association with dysplasia suggest that chemoprevention might be a useful adjunct therapy.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-004-9591-2