Stable Electroenzymatic Processes by Catalyst Separation

Division of labour: The rapid enzyme inactivation in the electroenzymatic synthesis of chiral alcohols has been the main obstacle for synthetic applications during the last two decades. The reasons for this inactivation have now been elucidated. The development of a water‐soluble polymeric mediator...

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Bibliographic Details
Published in:Chemistry : a European journal 2009-01, Vol.15 (20), p.4998-5001
Main Authors: Hildebrand, Falk, Lütz, Stephan
Format: Article
Language:English
Subjects:
Alcohol Dehydrogenase - metabolism
Alcohols - chemical synthesis
Alcohols - chemistry
Catalysis
electrocatalysis
electroenzymatic synthesis
enzyme catalysis
Lactobacillus brevis - enzymology
Molecular Structure
NADP - metabolism
Polymers - chemistry
rhodium
Solubility
synthetic methods
Water
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Summary:Division of labour: The rapid enzyme inactivation in the electroenzymatic synthesis of chiral alcohols has been the main obstacle for synthetic applications during the last two decades. The reasons for this inactivation have now been elucidated. The development of a water‐soluble polymeric mediator and the spatial separation of enzyme and mediator led to the first stable process and significantly improved catalyst utilisations (see picture). Division of labour: The rapid enzyme inactivation in the electroenzymatic synthesis of chiral alcohols has been the main obstacle for synthetic applications during the last two decades. The reasons for this inactivation have now been elucidated. The development of a water‐soluble polymeric mediator and the spatial separation of enzyme and mediator led to the first stable process and significantly improved catalyst utilisations (see picture).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.200900219