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Stable Electroenzymatic Processes by Catalyst Separation
Division of labour: The rapid enzyme inactivation in the electroenzymatic synthesis of chiral alcohols has been the main obstacle for synthetic applications during the last two decades. The reasons for this inactivation have now been elucidated. The development of a water‐soluble polymeric mediator...
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| Published in: | Chemistry : a European journal 2009-01, Vol.15 (20), p.4998-5001 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4429-1ecb0e2d9eb5ed0be05971c68c8e575b1beb7e52f0a26889e3c66916ebd450513 |
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| cites | cdi_FETCH-LOGICAL-c4429-1ecb0e2d9eb5ed0be05971c68c8e575b1beb7e52f0a26889e3c66916ebd450513 |
| container_end_page | 5001 |
| container_issue | 20 |
| container_start_page | 4998 |
| container_title | Chemistry : a European journal |
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| creator | Hildebrand, Falk Lütz, Stephan |
| description | Division of labour: The rapid enzyme inactivation in the electroenzymatic synthesis of chiral alcohols has been the main obstacle for synthetic applications during the last two decades. The reasons for this inactivation have now been elucidated. The development of a water‐soluble polymeric mediator and the spatial separation of enzyme and mediator led to the first stable process and significantly improved catalyst utilisations (see picture).
Division of labour: The rapid enzyme inactivation in the electroenzymatic synthesis of chiral alcohols has been the main obstacle for synthetic applications during the last two decades. The reasons for this inactivation have now been elucidated. The development of a water‐soluble polymeric mediator and the spatial separation of enzyme and mediator led to the first stable process and significantly improved catalyst utilisations (see picture). |
| doi_str_mv | 10.1002/chem.200900219 |
| format | article |
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Division of labour: The rapid enzyme inactivation in the electroenzymatic synthesis of chiral alcohols has been the main obstacle for synthetic applications during the last two decades. The reasons for this inactivation have now been elucidated. The development of a water‐soluble polymeric mediator and the spatial separation of enzyme and mediator led to the first stable process and significantly improved catalyst utilisations (see picture).</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.200900219</identifier><identifier>PMID: 19373800</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag</publisher><subject>Alcohol Dehydrogenase - metabolism ; Alcohols - chemical synthesis ; Alcohols - chemistry ; Catalysis ; electrocatalysis ; electroenzymatic synthesis ; enzyme catalysis ; Lactobacillus brevis - enzymology ; Molecular Structure ; NADP - metabolism ; Polymers - chemistry ; rhodium ; Solubility ; synthetic methods ; Water</subject><ispartof>Chemistry : a European journal, 2009-01, Vol.15 (20), p.4998-5001</ispartof><rights>Copyright © 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4429-1ecb0e2d9eb5ed0be05971c68c8e575b1beb7e52f0a26889e3c66916ebd450513</citedby><cites>FETCH-LOGICAL-c4429-1ecb0e2d9eb5ed0be05971c68c8e575b1beb7e52f0a26889e3c66916ebd450513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19373800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hildebrand, Falk</creatorcontrib><creatorcontrib>Lütz, Stephan</creatorcontrib><title>Stable Electroenzymatic Processes by Catalyst Separation</title><title>Chemistry : a European journal</title><addtitle>Chemistry</addtitle><description>Division of labour: The rapid enzyme inactivation in the electroenzymatic synthesis of chiral alcohols has been the main obstacle for synthetic applications during the last two decades. The reasons for this inactivation have now been elucidated. The development of a water‐soluble polymeric mediator and the spatial separation of enzyme and mediator led to the first stable process and significantly improved catalyst utilisations (see picture).
Division of labour: The rapid enzyme inactivation in the electroenzymatic synthesis of chiral alcohols has been the main obstacle for synthetic applications during the last two decades. The reasons for this inactivation have now been elucidated. The development of a water‐soluble polymeric mediator and the spatial separation of enzyme and mediator led to the first stable process and significantly improved catalyst utilisations (see picture).</description><subject>Alcohol Dehydrogenase - metabolism</subject><subject>Alcohols - chemical synthesis</subject><subject>Alcohols - chemistry</subject><subject>Catalysis</subject><subject>electrocatalysis</subject><subject>electroenzymatic synthesis</subject><subject>enzyme catalysis</subject><subject>Lactobacillus brevis - enzymology</subject><subject>Molecular Structure</subject><subject>NADP - metabolism</subject><subject>Polymers - chemistry</subject><subject>rhodium</subject><subject>Solubility</subject><subject>synthetic methods</subject><subject>Water</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqFkEFLwzAUgIMobk6vHqUnb50vSZMmRynTCROF6Tkk6RtW2nUmHVJ_vR0b7ujp8Xjf-w4fIdcUphSA3fkPbKYMQA8L1SdkTAWjKc-lOCVj0FmeSsH1iFzE-AkDJjk_JyOqec4VwJioZWddjcmsRt-FFtc_fWO7yievofUYI8bE9UlhO1v3sUuWuLFhuLfrS3K2snXEq8OckPeH2VsxTxcvj0_F_SL1WcZ0StE7QFZqdAJLcAhC59RL5RWKXDjq0OUo2Aosk0pp5F5KTSW6MhMgKJ-Q2713E9qvLcbONFX0WNd2je02GpkzLjOpBnC6B31oYwy4MptQNTb0hoLZtTK7Vuav1fBwczBvXYPlET_EGQC9B76rGvt_dKaYz56P8l_lEXXc</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Hildebrand, Falk</creator><creator>Lütz, Stephan</creator><general>WILEY‐VCH Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090101</creationdate><title>Stable Electroenzymatic Processes by Catalyst Separation</title><author>Hildebrand, Falk ; Lütz, Stephan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4429-1ecb0e2d9eb5ed0be05971c68c8e575b1beb7e52f0a26889e3c66916ebd450513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Alcohol Dehydrogenase - metabolism</topic><topic>Alcohols - chemical synthesis</topic><topic>Alcohols - chemistry</topic><topic>Catalysis</topic><topic>electrocatalysis</topic><topic>electroenzymatic synthesis</topic><topic>enzyme catalysis</topic><topic>Lactobacillus brevis - enzymology</topic><topic>Molecular Structure</topic><topic>NADP - metabolism</topic><topic>Polymers - chemistry</topic><topic>rhodium</topic><topic>Solubility</topic><topic>synthetic methods</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hildebrand, Falk</creatorcontrib><creatorcontrib>Lütz, Stephan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hildebrand, Falk</au><au>Lütz, Stephan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stable Electroenzymatic Processes by Catalyst Separation</atitle><jtitle>Chemistry : a European journal</jtitle><addtitle>Chemistry</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>15</volume><issue>20</issue><spage>4998</spage><epage>5001</epage><pages>4998-5001</pages><issn>0947-6539</issn><eissn>1521-3765</eissn><abstract>Division of labour: The rapid enzyme inactivation in the electroenzymatic synthesis of chiral alcohols has been the main obstacle for synthetic applications during the last two decades. The reasons for this inactivation have now been elucidated. The development of a water‐soluble polymeric mediator and the spatial separation of enzyme and mediator led to the first stable process and significantly improved catalyst utilisations (see picture).
Division of labour: The rapid enzyme inactivation in the electroenzymatic synthesis of chiral alcohols has been the main obstacle for synthetic applications during the last two decades. The reasons for this inactivation have now been elucidated. The development of a water‐soluble polymeric mediator and the spatial separation of enzyme and mediator led to the first stable process and significantly improved catalyst utilisations (see picture).</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag</pub><pmid>19373800</pmid><doi>10.1002/chem.200900219</doi><tpages>4</tpages></addata></record> |
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| ispartof | Chemistry : a European journal, 2009-01, Vol.15 (20), p.4998-5001 |
| issn | 0947-6539 1521-3765 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Alcohol Dehydrogenase - metabolism Alcohols - chemical synthesis Alcohols - chemistry Catalysis electrocatalysis electroenzymatic synthesis enzyme catalysis Lactobacillus brevis - enzymology Molecular Structure NADP - metabolism Polymers - chemistry rhodium Solubility synthetic methods Water |
| title | Stable Electroenzymatic Processes by Catalyst Separation |
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