Prognostic irrelevance of HLA-G in B-cell chronic lymphocytic leukemia

Summary In the last few years, it has been suggested that the involvement of human leukocyte antigen‐G (HLA‐G) in several tumoral processes and its likely participation as a factor of immune tolerance in malignant cells. Recently, positive HLA‐G surface expression has been associated with a poor pro...

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Bibliographic Details
Published in:International journal of laboratory hematology 2009-06, Vol.31 (3), p.327-337
Main Authors: PEREZ-CHACON, G., ROSADO, S., REBOLLEDA, N., LOSADA-FERNANDEZ, I., VARGAS, J. A., MORADO, M., JORDA, J., PEREZ-ACIEGO, P.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
B-Lymphocytes - immunology
Female
Histocompatibility Antigens Class I - analysis
HLA Antigens - analysis
HLA-G antigen
HLA-G Antigens
Humans
Kaplan-Meier Estimate
Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell - mortality
Male
Middle Aged
Prognosis
prognostic marker
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Summary:Summary In the last few years, it has been suggested that the involvement of human leukocyte antigen‐G (HLA‐G) in several tumoral processes and its likely participation as a factor of immune tolerance in malignant cells. Recently, positive HLA‐G surface expression has been associated with a poor prognosis in a small group of patients with B‐cell chronic lymphocytic leukemia (B‐CLL), a lymphoproliferative disorder characterized by a heterogeneous clinical course. In the present work, 169 patients suffering from B‐CLL were analyzed for the expression of HLA‐G by flow cytometry in order to verify its prognostic value in a larger cohort. We observed a low expression of this molecule on leukemic B cells and no significant relation to clinical data or progression‐free survival time, indicating that this molecule is not as good immunologic prognostic marker for B‐CLL as suggested.
ISSN:1751-5521
1751-553X
DOI:10.1111/j.1751-553X.2008.01030.x