Effect of hypoxia on metabolism and contractile function of the heart in rats with type 2 diabetes mellitus and abdominal obesity

Type 2 diabetes mellitus was modeled in newborn albino rat pups. Metabolism and contractile activity of isolated heart under conditions of hypoxia were studied on adult rats. Contractile activity of the myocardium in animals with type 2 diabetes mellitus and abdominal obesity decreased during hypoxi...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2004-09, Vol.138 (3), p.223-225
Main Authors: Kolbina, M V, Dolgikh, V T, Chesnokov, V I
Format: Article
Language:English
Subjects:
Animals
Cell Hypoxia
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - physiopathology
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - physiopathology
In Vitro Techniques
Myocardial Contraction - physiology
Myocardium - metabolism
Obesity - complications
Rats
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Summary:Type 2 diabetes mellitus was modeled in newborn albino rat pups. Metabolism and contractile activity of isolated heart under conditions of hypoxia were studied on adult rats. Contractile activity of the myocardium in animals with type 2 diabetes mellitus and abdominal obesity decreased during hypoxia. It was manifested in a decrease in systolic and developed pressure and disturbances in diastolic relaxation of the myocardium. Damage to cell membranes and increased secretion of aspartate transaminase into the coronary circulation were observed under conditions of energy deficit and activation of the anaerobic pathway of energy production. These changes became more pronounced with increasing the period of hypoxic exposure.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0004-0