Effect of hypoxia on metabolism and contractile function of the heart in rats with type 2 diabetes mellitus and abdominal obesity

Type 2 diabetes mellitus was modeled in newborn albino rat pups. Metabolism and contractile activity of isolated heart under conditions of hypoxia were studied on adult rats. Contractile activity of the myocardium in animals with type 2 diabetes mellitus and abdominal obesity decreased during hypoxi...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2004-09, Vol.138 (3), p.223-225
Main Authors: Kolbina, M V, Dolgikh, V T, Chesnokov, V I
Format: Article
Language:English
Subjects:
Animals
Cell Hypoxia
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - physiopathology
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - physiopathology
In Vitro Techniques
Myocardial Contraction - physiology
Myocardium - metabolism
Obesity - complications
Rats
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c326t-e2daa06ae00ad5c7e8d8a213f0607c3a3436b82ad57e9c662ac4487d08e4f07a3
cites cdi_FETCH-LOGICAL-c326t-e2daa06ae00ad5c7e8d8a213f0607c3a3436b82ad57e9c662ac4487d08e4f07a3
container_end_page 225
container_issue 3
container_start_page 223
container_title Bulletin of experimental biology and medicine
container_volume 138
creator Kolbina, M V
Dolgikh, V T
Chesnokov, V I
description Type 2 diabetes mellitus was modeled in newborn albino rat pups. Metabolism and contractile activity of isolated heart under conditions of hypoxia were studied on adult rats. Contractile activity of the myocardium in animals with type 2 diabetes mellitus and abdominal obesity decreased during hypoxia. It was manifested in a decrease in systolic and developed pressure and disturbances in diastolic relaxation of the myocardium. Damage to cell membranes and increased secretion of aspartate transaminase into the coronary circulation were observed under conditions of energy deficit and activation of the anaerobic pathway of energy production. These changes became more pronounced with increasing the period of hypoxic exposure.
doi_str_mv 10.1007/s10517-005-0004-0
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67237701</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>797002451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-e2daa06ae00ad5c7e8d8a213f0607c3a3436b82ad57e9c662ac4487d08e4f07a3</originalsourceid><addsrcrecordid>eNpdkU9r3DAQxUVJabZpP0AvQeTQm9uRZEvKMYT0DwR6ac9iLI9ZBdvaSDLJHvvNo-0uFHIQo9H83tPAY-yTgC8CwHzNAjphGoCuHmgbeMM2ojOqsVKKM7apj6ZprbXn7H3OD4cWtHjHzkWndXcNZsP-3o0j-cLjyLf7XXwOyOPCZyrYxynkmeMycB-XktCXMBEf16VeKlMVZUt8S5gKDwtPWDJ_CmXLy35HXPIhYE-FcnWbplDW_M8L-yHOYcGJx55yKPsP7O2IU6aPp3rB_ny7-337o7n_9f3n7c1945XUpSE5IIJGAsCh84bsYFEKNYIG4xWqVuneyjozdO21lujb1poBLLUjGFQX7PPRd5fi40q5uDlkX1fDheKanTZSGQOiglevwIe4prpxdvU_pduu7SokjpBPMedEo9ulMGPaOwHuEI47huNqOO4QjoOquTwZr_1Mw3_FKQ31AlH2i28</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213364545</pqid></control><display><type>article</type><title>Effect of hypoxia on metabolism and contractile function of the heart in rats with type 2 diabetes mellitus and abdominal obesity</title><source>Springer Nature</source><creator>Kolbina, M V ; Dolgikh, V T ; Chesnokov, V I</creator><creatorcontrib>Kolbina, M V ; Dolgikh, V T ; Chesnokov, V I</creatorcontrib><description>Type 2 diabetes mellitus was modeled in newborn albino rat pups. Metabolism and contractile activity of isolated heart under conditions of hypoxia were studied on adult rats. Contractile activity of the myocardium in animals with type 2 diabetes mellitus and abdominal obesity decreased during hypoxia. It was manifested in a decrease in systolic and developed pressure and disturbances in diastolic relaxation of the myocardium. Damage to cell membranes and increased secretion of aspartate transaminase into the coronary circulation were observed under conditions of energy deficit and activation of the anaerobic pathway of energy production. These changes became more pronounced with increasing the period of hypoxic exposure.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-005-0004-0</identifier><identifier>PMID: 15665907</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Cell Hypoxia ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - physiopathology ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - physiopathology ; In Vitro Techniques ; Myocardial Contraction - physiology ; Myocardium - metabolism ; Obesity - complications ; Rats</subject><ispartof>Bulletin of experimental biology and medicine, 2004-09, Vol.138 (3), p.223-225</ispartof><rights>Springer Science+Business Media, Inc. 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-e2daa06ae00ad5c7e8d8a213f0607c3a3436b82ad57e9c662ac4487d08e4f07a3</citedby><cites>FETCH-LOGICAL-c326t-e2daa06ae00ad5c7e8d8a213f0607c3a3436b82ad57e9c662ac4487d08e4f07a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15665907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kolbina, M V</creatorcontrib><creatorcontrib>Dolgikh, V T</creatorcontrib><creatorcontrib>Chesnokov, V I</creatorcontrib><title>Effect of hypoxia on metabolism and contractile function of the heart in rats with type 2 diabetes mellitus and abdominal obesity</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>Type 2 diabetes mellitus was modeled in newborn albino rat pups. Metabolism and contractile activity of isolated heart under conditions of hypoxia were studied on adult rats. Contractile activity of the myocardium in animals with type 2 diabetes mellitus and abdominal obesity decreased during hypoxia. It was manifested in a decrease in systolic and developed pressure and disturbances in diastolic relaxation of the myocardium. Damage to cell membranes and increased secretion of aspartate transaminase into the coronary circulation were observed under conditions of energy deficit and activation of the anaerobic pathway of energy production. These changes became more pronounced with increasing the period of hypoxic exposure.</description><subject>Animals</subject><subject>Cell Hypoxia</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>In Vitro Techniques</subject><subject>Myocardial Contraction - physiology</subject><subject>Myocardium - metabolism</subject><subject>Obesity - complications</subject><subject>Rats</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNpdkU9r3DAQxUVJabZpP0AvQeTQm9uRZEvKMYT0DwR6ac9iLI9ZBdvaSDLJHvvNo-0uFHIQo9H83tPAY-yTgC8CwHzNAjphGoCuHmgbeMM2ojOqsVKKM7apj6ZprbXn7H3OD4cWtHjHzkWndXcNZsP-3o0j-cLjyLf7XXwOyOPCZyrYxynkmeMycB-XktCXMBEf16VeKlMVZUt8S5gKDwtPWDJ_CmXLy35HXPIhYE-FcnWbplDW_M8L-yHOYcGJx55yKPsP7O2IU6aPp3rB_ny7-337o7n_9f3n7c1945XUpSE5IIJGAsCh84bsYFEKNYIG4xWqVuneyjozdO21lujb1poBLLUjGFQX7PPRd5fi40q5uDlkX1fDheKanTZSGQOiglevwIe4prpxdvU_pduu7SokjpBPMedEo9ulMGPaOwHuEI47huNqOO4QjoOquTwZr_1Mw3_FKQ31AlH2i28</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>Kolbina, M V</creator><creator>Dolgikh, V T</creator><creator>Chesnokov, V I</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200409</creationdate><title>Effect of hypoxia on metabolism and contractile function of the heart in rats with type 2 diabetes mellitus and abdominal obesity</title><author>Kolbina, M V ; Dolgikh, V T ; Chesnokov, V I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-e2daa06ae00ad5c7e8d8a213f0607c3a3436b82ad57e9c662ac4487d08e4f07a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Cell Hypoxia</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>In Vitro Techniques</topic><topic>Myocardial Contraction - physiology</topic><topic>Myocardium - metabolism</topic><topic>Obesity - complications</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kolbina, M V</creatorcontrib><creatorcontrib>Dolgikh, V T</creatorcontrib><creatorcontrib>Chesnokov, V I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kolbina, M V</au><au>Dolgikh, V T</au><au>Chesnokov, V I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of hypoxia on metabolism and contractile function of the heart in rats with type 2 diabetes mellitus and abdominal obesity</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><addtitle>Bull Exp Biol Med</addtitle><date>2004-09</date><risdate>2004</risdate><volume>138</volume><issue>3</issue><spage>223</spage><epage>225</epage><pages>223-225</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>Type 2 diabetes mellitus was modeled in newborn albino rat pups. Metabolism and contractile activity of isolated heart under conditions of hypoxia were studied on adult rats. Contractile activity of the myocardium in animals with type 2 diabetes mellitus and abdominal obesity decreased during hypoxia. It was manifested in a decrease in systolic and developed pressure and disturbances in diastolic relaxation of the myocardium. Damage to cell membranes and increased secretion of aspartate transaminase into the coronary circulation were observed under conditions of energy deficit and activation of the anaerobic pathway of energy production. These changes became more pronounced with increasing the period of hypoxic exposure.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>15665907</pmid><doi>10.1007/s10517-005-0004-0</doi><tpages>3</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0007-4888
ispartof Bulletin of experimental biology and medicine, 2004-09, Vol.138 (3), p.223-225
issn 0007-4888
1573-8221
language eng
recordid cdi_proquest_miscellaneous_67237701
source Springer Nature
subjects Animals
Cell Hypoxia
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - physiopathology
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - physiopathology
In Vitro Techniques
Myocardial Contraction - physiology
Myocardium - metabolism
Obesity - complications
Rats
title Effect of hypoxia on metabolism and contractile function of the heart in rats with type 2 diabetes mellitus and abdominal obesity
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T22%3A38%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20hypoxia%20on%20metabolism%20and%20contractile%20function%20of%20the%20heart%20in%20rats%20with%20type%202%20diabetes%20mellitus%20and%20abdominal%20obesity&rft.jtitle=Bulletin%20of%20experimental%20biology%20and%20medicine&rft.au=Kolbina,%20M%20V&rft.date=2004-09&rft.volume=138&rft.issue=3&rft.spage=223&rft.epage=225&rft.pages=223-225&rft.issn=0007-4888&rft.eissn=1573-8221&rft.coden=BEXBAN&rft_id=info:doi/10.1007/s10517-005-0004-0&rft_dat=%3Cproquest_cross%3E797002451%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c326t-e2daa06ae00ad5c7e8d8a213f0607c3a3436b82ad57e9c662ac4487d08e4f07a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=213364545&rft_id=info:pmid/15665907&rfr_iscdi=true