Effect of Enamel Matrix Derivative on Collagen Guided Tissue Regeneration‐Based Root Coverage Procedure

Background: Enamel matrix derivative (EMD) has been shown to promote periodontal wound healing and/or regeneration when applied to tooth root surfaces in soft tissue dehiscence models. In addition, guided tissue regeneration (GTR)‐based root coverage using collagen membrane (GTRC) has shown promisin...

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Published in:Journal of periodontology (1970) 2004-11, Vol.75 (11), p.1446-1457
Main Authors: Trabulsi, Manal, Oh, Tae‐Ju, Eber, Robert, Weber, Daniel, Wang, Hom‐Lay
Format: Article
Language:English
Subjects:
Absorbable Implants
Adult
Aged
Analysis of Variance
Biocompatible Materials - therapeutic use
Collagen - therapeutic use
Dental Enamel Proteins - therapeutic use
Dentistry
enamel matrix derivative
Female
Gingival Recession - classification
Gingival Recession - surgery
gingival recession/therapy
guided tissue regeneration
Guided Tissue Regeneration, Periodontal - methods
Humans
Male
membranes, barrier
membranes, bioabsorbable
Middle Aged
outcome assessment
Surgical Flaps
tooth root
wound healing
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Summary:Background: Enamel matrix derivative (EMD) has been shown to promote periodontal wound healing and/or regeneration when applied to tooth root surfaces in soft tissue dehiscence models. In addition, guided tissue regeneration (GTR)‐based root coverage using collagen membrane (GTRC) has shown promising results. However, limited information is available regarding how EMD may influence GTRC outcome. Methods: Twenty‐six patients with Miller's Class I or II gingival recession defects of 2.5 mm were recruited for the study. Subjects were randomly assigned to receive either EMD + collagen (EMDC; test group) or collagen membrane (GTRC; control group). Clinical parameters, including plaque index (PI), gingival index (GI), relative clinical attachment levels (RCAL) to the stent, recession depth (RD), recession width (RW), probing depth (PD), gingival tissue thickness (GTT), and width of keratinized gingiva (KG) were assessed at baseline, and 3 and 6 months after surgery. A repeated measure of analysis of variance (ANOVA) was used to determine differences between treatment groups and time effect. Results: Both treatments (GTRC and EMDC) resulted in a statistically significant decrease in RD and RW between baseline and 6 months (P
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2004.75.11.1446