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Effect of Enamel Matrix Derivative on Collagen Guided Tissue Regeneration‐Based Root Coverage Procedure
Background: Enamel matrix derivative (EMD) has been shown to promote periodontal wound healing and/or regeneration when applied to tooth root surfaces in soft tissue dehiscence models. In addition, guided tissue regeneration (GTR)‐based root coverage using collagen membrane (GTRC) has shown promisin...
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| Published in: | Journal of periodontology (1970) 2004-11, Vol.75 (11), p.1446-1457 |
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| container_end_page | 1457 |
| container_issue | 11 |
| container_start_page | 1446 |
| container_title | Journal of periodontology (1970) |
| container_volume | 75 |
| creator | Trabulsi, Manal Oh, Tae‐Ju Eber, Robert Weber, Daniel Wang, Hom‐Lay |
| description | Background: Enamel matrix derivative (EMD) has been shown to promote periodontal wound healing and/or regeneration when applied to tooth root surfaces in soft tissue dehiscence models. In addition, guided tissue regeneration (GTR)‐based root coverage using collagen membrane (GTRC) has shown promising results. However, limited information is available regarding how EMD may influence GTRC outcome.
Methods: Twenty‐six patients with Miller's Class I or II gingival recession defects of 2.5 mm were recruited for the study. Subjects were randomly assigned to receive either EMD + collagen (EMDC; test group) or collagen membrane (GTRC; control group). Clinical parameters, including plaque index (PI), gingival index (GI), relative clinical attachment levels (RCAL) to the stent, recession depth (RD), recession width (RW), probing depth (PD), gingival tissue thickness (GTT), and width of keratinized gingiva (KG) were assessed at baseline, and 3 and 6 months after surgery. A repeated measure of analysis of variance (ANOVA) was used to determine differences between treatment groups and time effect.
Results: Both treatments (GTRC and EMDC) resulted in a statistically significant decrease in RD and RW between baseline and 6 months (P |
| doi_str_mv | 10.1902/jop.2004.75.11.1446 |
| format | article |
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Methods: Twenty‐six patients with Miller's Class I or II gingival recession defects of 2.5 mm were recruited for the study. Subjects were randomly assigned to receive either EMD + collagen (EMDC; test group) or collagen membrane (GTRC; control group). Clinical parameters, including plaque index (PI), gingival index (GI), relative clinical attachment levels (RCAL) to the stent, recession depth (RD), recession width (RW), probing depth (PD), gingival tissue thickness (GTT), and width of keratinized gingiva (KG) were assessed at baseline, and 3 and 6 months after surgery. A repeated measure of analysis of variance (ANOVA) was used to determine differences between treatment groups and time effect.
Results: Both treatments (GTRC and EMDC) resulted in a statistically significant decrease in RD and RW between baseline and 6 months (P <0.05). However, no difference was noted between treatment groups. The percent of root coverage after 6 months was 75% for GTRC and 63% for EMDC. Complete 100% root coverage was achieved in five patients in the GTRC group, compared to only one patient in the EMDC group. There was a statistically significant gain (P <0.05) in the clinical attachment level (CAL) between baseline and 6 months in both groups, as reflected on the RCAL data. No other significant differences were noted on other clinical parameters (PD, GTT, KG, GI, and PI).
Conclusions: GTR‐based root coverage utilizing collagen membrane, with or without enamel matrix derivative, can be successfully used in obtaining gingival recession coverage. The application of EMD during GTRC procedures did not add additional benefit to the final clinical outcome. J Periodontol 2004;75:1446‐1457.</description><identifier>ISSN: 0022-3492</identifier><identifier>EISSN: 1943-3670</identifier><identifier>DOI: 10.1902/jop.2004.75.11.1446</identifier><identifier>PMID: 15633319</identifier><language>eng</language><publisher>737 N. Michigan Avenue, Suite 800, Chicago, IL 60611‐2690, USA: American Academy of Periodontology</publisher><subject>Absorbable Implants ; Adult ; Aged ; Analysis of Variance ; Biocompatible Materials - therapeutic use ; Collagen - therapeutic use ; Dental Enamel Proteins - therapeutic use ; Dentistry ; enamel matrix derivative ; Female ; Gingival Recession - classification ; Gingival Recession - surgery ; gingival recession/therapy ; guided tissue regeneration ; Guided Tissue Regeneration, Periodontal - methods ; Humans ; Male ; membranes, barrier ; membranes, bioabsorbable ; Middle Aged ; outcome assessment ; Surgical Flaps ; tooth root ; wound healing</subject><ispartof>Journal of periodontology (1970), 2004-11, Vol.75 (11), p.1446-1457</ispartof><rights>2004 American Academy of Periodontology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4196-67a847e3c92033c441b8f8d5048df3e17ddf1f66dbb6f83064ac74d81b506acf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15633319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trabulsi, Manal</creatorcontrib><creatorcontrib>Oh, Tae‐Ju</creatorcontrib><creatorcontrib>Eber, Robert</creatorcontrib><creatorcontrib>Weber, Daniel</creatorcontrib><creatorcontrib>Wang, Hom‐Lay</creatorcontrib><title>Effect of Enamel Matrix Derivative on Collagen Guided Tissue Regeneration‐Based Root Coverage Procedure</title><title>Journal of periodontology (1970)</title><addtitle>J Periodontol</addtitle><description>Background: Enamel matrix derivative (EMD) has been shown to promote periodontal wound healing and/or regeneration when applied to tooth root surfaces in soft tissue dehiscence models. In addition, guided tissue regeneration (GTR)‐based root coverage using collagen membrane (GTRC) has shown promising results. However, limited information is available regarding how EMD may influence GTRC outcome.
Methods: Twenty‐six patients with Miller's Class I or II gingival recession defects of 2.5 mm were recruited for the study. Subjects were randomly assigned to receive either EMD + collagen (EMDC; test group) or collagen membrane (GTRC; control group). Clinical parameters, including plaque index (PI), gingival index (GI), relative clinical attachment levels (RCAL) to the stent, recession depth (RD), recession width (RW), probing depth (PD), gingival tissue thickness (GTT), and width of keratinized gingiva (KG) were assessed at baseline, and 3 and 6 months after surgery. A repeated measure of analysis of variance (ANOVA) was used to determine differences between treatment groups and time effect.
Results: Both treatments (GTRC and EMDC) resulted in a statistically significant decrease in RD and RW between baseline and 6 months (P <0.05). However, no difference was noted between treatment groups. The percent of root coverage after 6 months was 75% for GTRC and 63% for EMDC. Complete 100% root coverage was achieved in five patients in the GTRC group, compared to only one patient in the EMDC group. There was a statistically significant gain (P <0.05) in the clinical attachment level (CAL) between baseline and 6 months in both groups, as reflected on the RCAL data. No other significant differences were noted on other clinical parameters (PD, GTT, KG, GI, and PI).
Conclusions: GTR‐based root coverage utilizing collagen membrane, with or without enamel matrix derivative, can be successfully used in obtaining gingival recession coverage. The application of EMD during GTRC procedures did not add additional benefit to the final clinical outcome. J Periodontol 2004;75:1446‐1457.</description><subject>Absorbable Implants</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biocompatible Materials - therapeutic use</subject><subject>Collagen - therapeutic use</subject><subject>Dental Enamel Proteins - therapeutic use</subject><subject>Dentistry</subject><subject>enamel matrix derivative</subject><subject>Female</subject><subject>Gingival Recession - classification</subject><subject>Gingival Recession - surgery</subject><subject>gingival recession/therapy</subject><subject>guided tissue regeneration</subject><subject>Guided Tissue Regeneration, Periodontal - methods</subject><subject>Humans</subject><subject>Male</subject><subject>membranes, barrier</subject><subject>membranes, bioabsorbable</subject><subject>Middle Aged</subject><subject>outcome assessment</subject><subject>Surgical Flaps</subject><subject>tooth root</subject><subject>wound healing</subject><issn>0022-3492</issn><issn>1943-3670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqNkMFu1DAQhi0EotvCEyAhn7gleGLHSY6w3RaqIqpVOVuOPa5cZePFThZ66yP0GXkSvOxKvXIazfj7f1kfIe-AldCx6uN92JYVY6Js6hKgBCHkC7KATvCCy4a9JAvGqqrgoqtOyGlK93kFwdlrcgK15JxDtyB-5RyaiQZHV6Pe4EC_6Sn63_Qco9_pye-QhpEuwzDoOxzp5ewtWnrrU5qRrjHfMGYsjH8enz7rlN_WIUw5sMv3O6Q3MRi0c8Q35JXTQ8K3x3lGflysbpdfiuvvl1-Xn64LI6CThWx0KxrkpqsY50YI6FvX2pqJ1jqO0FjrwElp-166ljMptGmEbaGvmdTG8TPy4dC7jeHnjGlSG58M5v-PGOakZFPxllUig_wAmhhSiujUNvqNjg8KmNobVtmw2htWTa0A1N5wTr0_1s_9Bu1z5qg0A90B-OUHfPifTnV1s1r_K_8LWoqKhg</recordid><startdate>200411</startdate><enddate>200411</enddate><creator>Trabulsi, Manal</creator><creator>Oh, Tae‐Ju</creator><creator>Eber, Robert</creator><creator>Weber, Daniel</creator><creator>Wang, Hom‐Lay</creator><general>American Academy of Periodontology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200411</creationdate><title>Effect of Enamel Matrix Derivative on Collagen Guided Tissue Regeneration‐Based Root Coverage Procedure</title><author>Trabulsi, Manal ; Oh, Tae‐Ju ; Eber, Robert ; Weber, Daniel ; Wang, Hom‐Lay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4196-67a847e3c92033c441b8f8d5048df3e17ddf1f66dbb6f83064ac74d81b506acf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Absorbable Implants</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biocompatible Materials - therapeutic use</topic><topic>Collagen - therapeutic use</topic><topic>Dental Enamel Proteins - therapeutic use</topic><topic>Dentistry</topic><topic>enamel matrix derivative</topic><topic>Female</topic><topic>Gingival Recession - classification</topic><topic>Gingival Recession - surgery</topic><topic>gingival recession/therapy</topic><topic>guided tissue regeneration</topic><topic>Guided Tissue Regeneration, Periodontal - methods</topic><topic>Humans</topic><topic>Male</topic><topic>membranes, barrier</topic><topic>membranes, bioabsorbable</topic><topic>Middle Aged</topic><topic>outcome assessment</topic><topic>Surgical Flaps</topic><topic>tooth root</topic><topic>wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trabulsi, Manal</creatorcontrib><creatorcontrib>Oh, Tae‐Ju</creatorcontrib><creatorcontrib>Eber, Robert</creatorcontrib><creatorcontrib>Weber, Daniel</creatorcontrib><creatorcontrib>Wang, Hom‐Lay</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontology (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trabulsi, Manal</au><au>Oh, Tae‐Ju</au><au>Eber, Robert</au><au>Weber, Daniel</au><au>Wang, Hom‐Lay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Enamel Matrix Derivative on Collagen Guided Tissue Regeneration‐Based Root Coverage Procedure</atitle><jtitle>Journal of periodontology (1970)</jtitle><addtitle>J Periodontol</addtitle><date>2004-11</date><risdate>2004</risdate><volume>75</volume><issue>11</issue><spage>1446</spage><epage>1457</epage><pages>1446-1457</pages><issn>0022-3492</issn><eissn>1943-3670</eissn><abstract>Background: Enamel matrix derivative (EMD) has been shown to promote periodontal wound healing and/or regeneration when applied to tooth root surfaces in soft tissue dehiscence models. In addition, guided tissue regeneration (GTR)‐based root coverage using collagen membrane (GTRC) has shown promising results. However, limited information is available regarding how EMD may influence GTRC outcome.
Methods: Twenty‐six patients with Miller's Class I or II gingival recession defects of 2.5 mm were recruited for the study. Subjects were randomly assigned to receive either EMD + collagen (EMDC; test group) or collagen membrane (GTRC; control group). Clinical parameters, including plaque index (PI), gingival index (GI), relative clinical attachment levels (RCAL) to the stent, recession depth (RD), recession width (RW), probing depth (PD), gingival tissue thickness (GTT), and width of keratinized gingiva (KG) were assessed at baseline, and 3 and 6 months after surgery. A repeated measure of analysis of variance (ANOVA) was used to determine differences between treatment groups and time effect.
Results: Both treatments (GTRC and EMDC) resulted in a statistically significant decrease in RD and RW between baseline and 6 months (P <0.05). However, no difference was noted between treatment groups. The percent of root coverage after 6 months was 75% for GTRC and 63% for EMDC. Complete 100% root coverage was achieved in five patients in the GTRC group, compared to only one patient in the EMDC group. There was a statistically significant gain (P <0.05) in the clinical attachment level (CAL) between baseline and 6 months in both groups, as reflected on the RCAL data. No other significant differences were noted on other clinical parameters (PD, GTT, KG, GI, and PI).
Conclusions: GTR‐based root coverage utilizing collagen membrane, with or without enamel matrix derivative, can be successfully used in obtaining gingival recession coverage. The application of EMD during GTRC procedures did not add additional benefit to the final clinical outcome. J Periodontol 2004;75:1446‐1457.</abstract><cop>737 N. Michigan Avenue, Suite 800, Chicago, IL 60611‐2690, USA</cop><pub>American Academy of Periodontology</pub><pmid>15633319</pmid><doi>10.1902/jop.2004.75.11.1446</doi><tpages>12</tpages></addata></record> |
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| ispartof | Journal of periodontology (1970), 2004-11, Vol.75 (11), p.1446-1457 |
| issn | 0022-3492 1943-3670 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Absorbable Implants Adult Aged Analysis of Variance Biocompatible Materials - therapeutic use Collagen - therapeutic use Dental Enamel Proteins - therapeutic use Dentistry enamel matrix derivative Female Gingival Recession - classification Gingival Recession - surgery gingival recession/therapy guided tissue regeneration Guided Tissue Regeneration, Periodontal - methods Humans Male membranes, barrier membranes, bioabsorbable Middle Aged outcome assessment Surgical Flaps tooth root wound healing |
| title | Effect of Enamel Matrix Derivative on Collagen Guided Tissue Regeneration‐Based Root Coverage Procedure |
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