Gonadotrophin Inhibitory Hormone Depresses Gonadotrophin α and Follicle-Stimulating Hormone β Subunit Expression in the Pituitary of the Domestic Chicken

Studies performed in vitro suggest that a novel 12 amino acid RF amide peptide, isolated from the quail hypothalamus, is a gonadotrophin inhibitory hormone (GnIH). The aim of the present study was to investigate this hypothesis in the domestic chicken. Injections of GnIH into nest‐deprived incubatin...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2004-12, Vol.16 (12), p.999-1006
Main Authors: Ciccone, N. A., Dunn, I. C., Boswell, T., Tsutsui, K., Ubuka, T., Ukena, K., Sharp, P. J.
Format: Article
Language:English
Subjects:
Animals
Avian Proteins - physiology
Biological and medical sciences
chicken
Chickens
Female
Follicle Stimulating Hormone, beta Subunit - genetics
Follicle Stimulating Hormone, beta Subunit - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Glycoprotein Hormones, alpha Subunit - genetics
Glycoprotein Hormones, alpha Subunit - metabolism
GnIH
gonadotrophin mRNAs
Hypothalamic Hormones - physiology
hypothalamus
In Vitro Techniques
Luteinizing Hormone - blood
Male
Nesting Behavior - physiology
Ovary - metabolism
Pituitary Gland, Anterior - metabolism
reproduction
Reproduction - physiology
RNA, Messenger - analysis
Sex Factors
Vertebrates: endocrinology
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Summary:Studies performed in vitro suggest that a novel 12 amino acid RF amide peptide, isolated from the quail hypothalamus, is a gonadotrophin inhibitory hormone (GnIH). The aim of the present study was to investigate this hypothesis in the domestic chicken. Injections of GnIH into nest‐deprived incubating hens failed to depress the concentration of plasma luteinizing hormone (LH). Addition of GnIH to short‐term (120 min) cultures of diced pituitary glands from adult cockerels depressed follicle‐stimulating hormone (FSH) and LH release and depressed common α and FSHβ gonadotrophin subunit mRNAs, with no effect on LHβ subunit mRNA. Hypothalamic GnIH mRNA was higher in incubating (out‐of‐lay) than in laying hens, but there was no significant difference in the amount of hypothalamic GnIH mRNA in out‐of‐lay and laying broiler breeder hens at the end of a laying year. It is concluded that avian GnIH may play a role in controlling gonadotrophin synthesis and associated constitutive release in the domestic chicken.
ISSN:0953-8194
1365-2826
DOI:10.1111/j.1365-2826.2005.01260.x