Changes in Estrogen Receptor, Progesterone Receptor and Her-2/neu Status with Time: Discordance Rates Between Primary and Metastatic Breast Cancer

Background: Changes in the receptor profile between primary and metastatic breast cancer tissue have been suggested. The degree of hormone receptor discordance in archival paired pathological samples was evaluated. Materials and Methods: Archival data were collected on 100 patients for whom tissue f...

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Bibliographic Details
Published in:Anticancer research 2009-05, Vol.29 (5), p.1557-1562
Main Authors: BROOM, Reuben J, TANG, Patricia A, SUMMONS, Christine, BORDELEAU, Louise, MULLIGAN, Anna Marie, O'MALLEY, Frances P, MILLER, Naomi, ANDRULIS, Irene L, BRENNER, Darren M, LEMONS, Mark J
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Middle Aged
Neoplasm Metastasis
Receptor, ErbB-2 - metabolism
Receptors, Estrogen - metabolism
Receptors, Progesterone - metabolism
Tumors
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Summary:Background: Changes in the receptor profile between primary and metastatic breast cancer tissue have been suggested. The degree of hormone receptor discordance in archival paired pathological samples was evaluated. Materials and Methods: Archival data were collected on 100 patients for whom tissue from primary and metastatic sites was available. Estrogen receptor (ER), progesterone receptor (PR) and Her-2/neu status in the primary and metastasis were compared. Results: The discordance rate for ER was 17.7% (2-sided p=0.0039) with 9.7% of tumours changing from ER-positive to ER-negative and 8.0% changing from ER-negative to ER-positive. The discordance rate for PR was 37.3% (2-sided p
ISSN:0250-7005
1791-7530